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Review

Islet Cell Replacement Therapy for Insulin-Dependent Diabetes

Brit Cooper-Jones, Caitlyn Ford
In: CADTH Issues in Emerging Health Technologies. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2016. 157.
CADTH Horizon Scans.
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Review

Islet Cell Replacement Therapy for Insulin-Dependent Diabetes

Brit Cooper-Jones et al.
Free Books & Documents

Excerpt

  1. ViaCyte’s PEC-Direct and PEC-Encap (VC-01) products offer a potential “functional cure” for patients with type 1 diabetes and insulin-dependent type 2 diabetes.

  2. Using human pancreatic progenitor cells (PEC-01) created in the lab, both the PEC-Direct and the PEC-Encap products are implanted into patients, where they mature into functional pancreatic islet tissue that includes glucose-responsive insulin-producing beta cells.

  3. The PEC-Encap product offers the additional benefit of an encapsulation device designed to protect the cells from the immune system.

  4. The current evidence is limited to phase I and II human trials evaluating the safety of the PEC-Encap product and pre-clinical study of the PEC-Direct product.

  5. There are insufficient data about efficacy in humans, adverse effects, and the length of time the product can remain safely implanted and functional.

  6. The future cost of ViaCyte’s products is unknown.

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References

    1. Cell replacement therapy [Internet] Hollywood (FL): Diabetes Research Institute Foundation; 2016. [cited 2017 Feb 27]. Available from: https://www.diabetesresearch.org/cell-replacement-therapy.
    1. Canadian Diabetes Association Clinical Practice Guidelines Expert Committee. Goldenberg R, Punthakee Z. Definition, classification and diagnosis of diabetes, prediabetes and metabolic syndrome. Can J Diabetes. 2013 Apr;37 Suppl 1:S8–11. - PubMed
    1. ViaCyte [Internet] San Diego (CA): ViaCyte; 2017. [cited 2017 Feb 14]. Available from: http://viacyte.com/
    1. The Edmonton protocol [Internet] Edmonton: University of Alberta, Alberta Diabetes Institute; 2017. [cited 2017 Feb 14]. Available from: http://adi.ualberta.ca/en/ResearchAreas/IsletCellBiologyandPhysiology/On....
    1. Desai T, Shea LD. Advances in islet encapsulation technologies. Nat Rev Drug Discov. 2016 Dec 23; - PubMed

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