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Comparative Study
. 2018 Mar;20(3):508-514.
doi: 10.1111/jch.13201. Epub 2018 Jan 25.

Performance of 4 definitions of childhood elevated blood pressure in predicting subclinical cardiovascular outcomes in adulthood

Hui Fan  1   2 , Dongqing Hou  1 , Junting Liu  1 , Yinkun Yan  1 , Jie Mi  1   2
Affiliations
Comparative Study

Performance of 4 definitions of childhood elevated blood pressure in predicting subclinical cardiovascular outcomes in adulthood

Hui Fan et al. J Clin Hypertens (Greenwich). 2018 Mar.

Abstract

We aimed to compare the ability of the pediatric blood pressure (BP) standards issued by the US Fourth Report, the recently proposed US, Chinese, and international standards to predict adult hypertension and subclinical cardiovascular disease (CVD). 2296 children were randomly selected from Beijing at baseline. The follow-up survey was conducted among 1177 adults. Subclinical adult CVD was assessed using the carotid-femoral pulse wave velocity (cfPWV), carotid intima-media thickness (CIMT), and left ventricular mass index (LVMI). The prevalence of pediatric elevated BP was significantly higher according to the Chinese standards vs the Fourth Report, the updated US standards, and the international standards (18.7% vs 14.2%, 17.5%, and 18.0%, respectively; all Ps < .001). Children identified as elevated BP using any of the 4 standards were more likely to have adult hypertension, high cfPWV, and high LVMI than children without elevated BP. However, only the Chinese and updated US standards can predict the increased risk of adult high CIMT. Our results indicated that the Chinese standards performed equally or better compared with 3 other standards in predicting adult hypertension and subclinical CVD.

Keywords: blood pressure; cardiovascular disease; child.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Prevalence of childhood elevated BP and hypertension among 4 different standards at baseline. *P < .001 (Compared with the Chinese standards). BP, blood pressure
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