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Review
. 2018 Jan 31;41(1):45-49.
doi: 10.14348/molcells.2018.2265. Epub 2018 Jan 23.

Development of Research into Autophagic Lysosome Reformation

Yang Chen  1 , Li Yu  1
Affiliations
Review

Development of Research into Autophagic Lysosome Reformation

Yang Chen et al. Mol Cells. .

Abstract

Autophagy is a lysosome-dependent degradation process that is essential for maintaining cellular homeostasis. In recent years, more studies have focused on the late stages of autophagy. Our group discovered and studied the terminal step of autophagy, namely autophagic lysosome reformation (ALR). ALR is the process that regenerates functional lysosomes from autolysosomes, thus maintaining lysosome homeostasis. ALR involves clathrin-mediated membrane budding from autolysosomes, elongation of membrane tubules along microtubules with the pulling force provided by the motor protein KIF5B, proto-lysosome scission by dynamin 2, and finally maturation of proto-lysosomes to functional lysosomes. In this review, we will summarize progress in unveiling the molecular mechanisms underlying ALR and its potential pathophysiological roles.

Keywords: autophagic lysosome reformation (ALR); autophagy; in vitro reconstitution; membrane deformation; phospholipid.

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Figures

Fig. 1
Fig. 1. Schematic illustration of the correlation between mTOR activity and autophagy during starvation
Fig. 2
Fig. 2. Schematic illustration of the process of ALR involving clathrin-mediated membrane budding from autolysosomes, elongation of membrane tubules along microtubules by the motor protein KIF5B and proto-lysosome scission by dynamin 2
See this image and copyright information in PMC

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