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. 2018 Jan 25;18(1):18.
doi: 10.1186/s12876-018-0748-4.

Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio can predict the severity of gallstone pancreatitis

Seung Kook Cho  1 , Saehyun Jung  1 , Kyong Joo Lee  2 , Jae Woo Kim  3
Affiliations

Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio can predict the severity of gallstone pancreatitis

Seung Kook Cho et al. BMC Gastroenterol. .

Abstract

Background: Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) predict severity in various diseases. In this study, we evaluated the value of NLR and PLR as prognostic factors in acute pancreatitis (AP).

Methods: Patients with AP were prospectively enrolled from March 2014 to September 2016 at Yonsei University Wonju College of Medicine. NLR and PLR were obtained at admission and were compared with other known prognostic scoring systems.

Results: A total of 243 patients were enrolled with an etiology of gallstone (n = 134) or alcohol (n = 109). NLR (17.7 ± 18.3 vs. 8.8 ± 8.4, P < 0.001) and PLR (344.1 ± 282.6 vs. 177.8 ± 150.1, P < 0.001) were significantly higher in the gallstone AP group than in the alcoholic AP group. For gallstone AP, NLR and PLR were significantly higher in severe AP, whereas high NLR and PLR were not related to severe AP in alcoholic AP. For the gallstone AP group, NLR and PLR demonstrated a predictive value significantly superior to C-reactive protein (CRP), whereas NLR, PLR, and CRP were not significant predictors for alcoholic AP.

Conclusion: Our study demonstrated that NLR and PLR can predict the severity of AP, but only in gallstone AP.

Keywords: Acute pancreatitis; Gallstone; Neutrophil to lymphocyte ratio; Platelet to lymphocyte ratio; Severity.

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Conflict of interest statement

Ethics approval

The International Review Board for Human Research of Yonsei University Wonju College of Medicine approved this study (CR315005–002). Written informed consent was obtained from all patients.

Consent for publication

Not applicable

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Flow chart of patient enrollment
Fig. 2
Fig. 2
ROC curve to predict persistent organ failure. a In all cases, (b) In gallstone pancreatitis, (c) In alcoholic pancreatitis
See this image and copyright information in PMC

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