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Observational Study
. 2018 Jan 25;18(1):18.
doi: 10.1186/s12890-018-0574-z.

Predictors of one-year mortality after hospitalization for an exacerbation of COPD

Cristóbal Esteban  1   2 , Ady Castro-Acosta  3   4 , Carlos Jose Alvarez-Martínez  3   4 , Alberto Capelastegui  5 , José Luis López-Campos  6 , Francisco Pozo-Rodriguez  3   4
Affiliations
Observational Study

Predictors of one-year mortality after hospitalization for an exacerbation of COPD

Cristóbal Esteban et al. BMC Pulm Med. .

Abstract

Background: Hospitalization for a severe exacerbation of COPD (eCOPD) is an important event in the natural history of COPD. Identifying factors related to mortality 1 year after hospitalization could help determine interventions to reduce mortality.

Methods: In a prospective, observational, multicentre study, we evaluated data from two cohorts: the Spanish audit of hospital COPD exacerbation care (our derivation sample) and the Spanish cohort of the European audit of COPD exacerbation care (our validation sample). The endpoint was all-cause mortality. Mortality was determined by local research managers of the participating hospitals and matched the official national index records in Spain.

Results: In the multivariate analysis, factors independently related to an increase in mortality were older age, cardio-cerebro-vascular and/or dementia comorbidities, PaCO2 > 55 mmHg measured at emergency department arrival, hospitalizations for COPD exacerbations in the previous year, and hospital characteristics. The area under the receiver-operating curve for this model was 0.75 in the derivation cohort and 0.76 in the validation cohort.

Conclusion: One-year mortality following the index hospitalization for an exacerbation of COPD was related to clinical characteristics of the patient and of the index event, previous events of similar severity, and characteristics of the hospital where the patient was treated.

Keywords: Chronic obstructive; Hospitalization; Mortality; Pulmonary disease.

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Conflict of interest statement

Ethics approval and consent to participate

The study was approved by Instituto de Salud Carlos III CEI PI 30_2011-v4 and by the Ethics Committees of every hospital involved in the study. All participants provided written informed consent.

Consent for publication

Not applicable

Competing interests

The authors declare that they have no competing interests.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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