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Comment
. 2018 Mar;8(3):259-260.
doi: 10.1158/2159-8290.CD-ND2018-002. Epub 2018 Jan 25.

STINGing Antitumor Immunity into Action

No authors listed
Comment

STINGing Antitumor Immunity into Action

No authors listed. Cancer Discov. 2018 Mar.

Abstract

Efforts to stimulate STING signaling, thereby turning immunologically "cold" tumors "hot" and receptive to immunotherapy, are gaining ground in the industry. To date, directly targeting the STING receptor with synthetic ligands is the main approach to have entered clinical trials, but indirect small-molecule modulators of the pathway are also being pursued.

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