Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Mar;29(3):710-712.
doi: 10.1681/ASN.2017111197. Epub 2018 Jan 25.

The Benefits of Tubular Proteinuria: An Evolutionary Perspective

Matias Simons  1
Affiliations

The Benefits of Tubular Proteinuria: An Evolutionary Perspective

Matias Simons. J Am Soc Nephrol. 2018 Mar.
No abstract available

Keywords: albuminuria; genetic renal disease; progression of renal failure; proximal tubule.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
The role of proximal tubular reabsorption in normal and proteinuric conditions. On the left, normal filtration and reabsorption of proteins, protein-bound lipids and toxins (such as drugs) is depicted. Protein and lipid catabolism in lysosomes and mitochondria is important to meet energy demands of PTC. In glomerular diseases, such as nephrotic syndrome or diabetic nephropathy (DN), PTC are exposed to protein, lipid and toxin overload (middle). Particularly, saturated fatty acids bound to albumin are known to cause cell damage through endoplasmic reticulum stress. Damage may be prevented by reducing PTC uptake, e.g. in patients with CUBN/AMN mutations (right).
See this image and copyright information in PMC

References

    1. Zoja C, Abbate M, Remuzzi G: Progression of renal injury toward interstitial inflammation and glomerular sclerosis is dependent on abnormal protein filtration. Nephrol Dial Transplant 30: 706–712, 2015 - PubMed
    1. Moorhead JF, Chan MK, El-Nahas M, Varghese Z: Lipid nephrotoxicity in chronic progressive glomerular and tubulo-interstitial disease. Lancet 2: 1309–1311, 1982 - PubMed
    1. Nielsen R, Christensen EI, Birn H: Megalin and cubilin in proximal tubule protein reabsorption: From experimental models to human disease. Kidney Int 89: 58–67, 2016 - PubMed
    1. Willnow TE, Christ A: Endocytic receptor LRP2/megalin-of holoprosencephaly and renal Fanconi syndrome. Pflugers Arch 469: 907–916, 2017 - PubMed
    1. Weyer K, Andersen PK, Schmidt K, Mollet G, Antignac C, Birn H, et al. : Abolishment of proximal tubule albumin endocytosis does not affect plasma albumin during nephrotic syndrome in mice [published online ahead of print October 13, 2017]. Kidney Int - PubMed

MeSH terms