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. 2018 Mar 5;47(5):1773-1782.
doi: 10.1039/c7cs00386b.

A continuing challenge: N-heterocyclic carbene-catalyzed syntheses of γ-butyrolactones

Kathleen J R Murauski  1 , Ashley A Jaworski, Karl A Scheidt
Affiliations

A continuing challenge: N-heterocyclic carbene-catalyzed syntheses of γ-butyrolactones

Kathleen J R Murauski et al. Chem Soc Rev. .

Abstract

Catalytic, stereoselective N-heterocyclic carbene-catalyzed reactions facilitate efficient construction of many different heterocyclic compounds, such as the enantioenriched 5-membered (γ) lactones highlighted in this tutorial review. Herein, various strategies to enable formal [3+2] type annulations between electrophilic carbonyl equivalents and homoenolate nucleophiles for the synthesis of γ-lactones are summarized.

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