Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Dec;76(12):6323-5.
doi: 10.1073/pnas.76.12.6323.

Changes in activity of fructose-1,6-bisphosphate aldolase in livers of fasted rabbits and accumulation of crossreacting immune material

S Pontremoli, E Melloni, F Salamino, B Sparatore, M Michetti, B L Horecker

Changes in activity of fructose-1,6-bisphosphate aldolase in livers of fasted rabbits and accumulation of crossreacting immune material

S Pontremoli et al. Proc Natl Acad Sci U S A. 1979 Dec.

Abstract

The activity of fructose-1,6-bisphosphate aldolase (D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase, EC 4.1.2.13) in livers of fasted rabbits decreases to less than one-half the value found in livers of fed rabbits. However, the concentration of aldolase protein in the liver extracts, measured with a specific antibody, remains unchanged. More than twice as much antibody is required to neutralize the aldolase activity in liver extracts from fasted compared with fed rabbits. The results suggest that modification of liver aldolase occurs during fasting, resulting in loss of catalytic activity without loss of immunoreactivity.

PubMed Disclaimer

References

    1. Arch Biochem Biophys. 1977 Aug;182(2):563-72 - PubMed
    1. Arch Biochem Biophys. 1978 Dec;191(2):825-7 - PubMed
    1. J Biol Chem. 1973 Feb 10;248(3):763-70 - PubMed
    1. Proc Natl Acad Sci U S A. 1973 Mar;70(3):909-13 - PubMed
    1. J Biol Chem. 1969 Jul 25;244(14):3913-9 - PubMed

Substances

LinkOut - more resources