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Comparative Study
. 1986 Jan-Feb;23(1-2):491-509.
doi: 10.1002/ajmg.1320230141.

Mouse chromosome fragility

M M Sanz, E C Jenkins, W T Brown, M T Davisson, M J Kevin, T H Roderick, W P Silverman, H M Wisniewski
Comparative Study

Mouse chromosome fragility

M M Sanz et al. Am J Med Genet. 1986 Jan-Feb.

Abstract

When cultures of fibroblast-like cells from inbred mouse strains RBC/Dn and AEJ/GnRk were exposed to 5-fluorodeoxyuridine (FUdR), non-random strain-specific distributions of chromosome gaps, breaks and exchanges were observed. Throughout the genomes there appeared to be specific sites at which lesions occurred preferentially. Two strain-specific fragile sites were identified in strain RBC/Dn at G-band 15A2, and at G-band 19B in strain AEJ/GnRk. Constitutive fragile sites at G-bands 12A2 and 18A2 were identified in both strains. A strain-specific marker at G-band 9B was found in strain AEJ/GnRk. The fragile sites reported here provide an animal model for the study of chromosome fragility as well as polymorphic markers for linkage studies.

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