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Review
. 2018 Jan 26;19(2):377.
doi: 10.3390/ijms19020377.

Autoimmunity and Gastric Cancer

Nicola Bizzaro  1 , Antonio Antico  2 , Danilo Villalta  3
Affiliations
Review

Autoimmunity and Gastric Cancer

Nicola Bizzaro et al. Int J Mol Sci. .

Abstract

Alterations in the immune response of patients with autoimmune diseases may predispose to malignancies, and a link between chronic autoimmune gastritis and gastric cancer has been reported in many studies. Intestinal metaplasia with dysplasia of the gastric corpus-fundus mucosa and hyperplasia of chromaffin cells, which are typical features of late-stage autoimmune gastritis, are considered precursor lesions. Autoimmune gastritis has been associated with the development of two types of gastric neoplasms: intestinal type and type I gastric carcinoid. Here, we review the association of autoimmune gastritis with gastric cancer and other autoimmune features present in gastric neoplasms.

Keywords: Helicobacter pylori infection; autoimmune diseases; autoimmune gastritis; gastric cancer; intrinsic factor antibodies; parietal cell antibodies.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
OLGA (operative link for gastritis assessment) staging system for gastritis. Modified from Rugge M. et al. [65].
See this image and copyright information in PMC

References

    1. Burnham T.K. Antinuclear antibodies in patients with malignancies. Lancet. 1972;2:436–437. doi: 10.1016/S0140-6736(72)91842-9. - DOI - PubMed
    1. Zermosky J.O., Gormy M.K., Jarczewska K. Malignancy associated with antinuclear antibodies. Lancet. 1972;2:1035–1036. doi: 10.1016/S0140-6736(72)92453-1. - DOI - PubMed
    1. Solans-Laqué R., Pérez-Bocanegra C., Salud-Salvia A., Fonollosa-Plá V., Rodrigo M.J., Armadans L., Simeón-Aznar C.P., Vilardell-Tarres M. Clinical significance of antinuclear antibodies in malignant diseases: Association with rheumatic and connective tissue paraneoplastic syndromes. Lupus. 2004;13:159–164. doi: 10.1191/0961203304lu521oa. - DOI - PubMed
    1. Atalay C., Atalay G., Yilmaz K.B., Altinok M. The role of anti-CENP-B and anti-SS-B antibodies in breast cancer. Neoplasma. 2005;52:32–35. - PubMed
    1. Toubi E., Shoenfeld Y. protective autoimmunity in cancer. Oncol. Rep. 2007;17:245–251. - PubMed

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