Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Dec;76(12):6500-4.
doi: 10.1073/pnas.76.12.6500.

Human heterozygosity: a new estimate

E H McConkey, B J Taylor, D Phan

Human heterozygosity: a new estimate

E H McConkey et al. Proc Natl Acad Sci U S A. 1979 Dec.

Abstract

Several hundred polypeptides from four human diploid fibroblast cell lines were compared by high-resolution two-dimensional polyacrylamide gel electrophoresis and double-label autoradiography under conditions where allelic products that differ by a single charged amino acid would be distinguished. The average heterozygosity represented by this set of gene products appears to be less than 1% for changes involving charged amino acids.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1978 Mar;75(3):1091-5 - PubMed
    1. J Biol Chem. 1969 Aug 25;244(16):4406-12 - PubMed
    1. Cell. 1977 Mar;10(3):381-91 - PubMed
    1. Prog Nucleic Acid Res Mol Biol. 1979;22:293-26 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 May;76(5):2381-4 - PubMed

LinkOut - more resources