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. 2019 Mar 28;8(1):55-59.
doi: 10.1093/jpids/pix105.

Results of a Targeted Screening Program for Congenital Cytomegalovirus Infection in Infants Who Fail Newborn Hearing Screening

Emily Vancor  1 , Eugene D Shapiro  1 , Jaspreet Loyal  1
Affiliations

Results of a Targeted Screening Program for Congenital Cytomegalovirus Infection in Infants Who Fail Newborn Hearing Screening

Emily Vancor et al. J Pediatric Infect Dis Soc. .

Abstract

Background: Congenital cytomegalovirus (CMV) infection is a major cause of sensorineural hearing loss. By law, newborns in Connecticut who fail newborn hearing screening are tested for infection with CMV. This targeted screening is controversial, because most children with congenital CMV infection are asymptomatic, and CMV-related hearing loss can have a delayed onset. Our hospital uses a saliva polymerase chain reaction (PCR) assay (confirmed by a urine PCR assay) to detect CMV. Here, we report the results of the first year of our screening program.

Methods: We reviewed the medical records of newborns in the Yale New Haven Health System who failed the newborn hearing screening test between January 1 and December 31, 2016.

Results: Of 10964 newborns, 171 failed newborn hearing screening, and 3 of these newborns had positive saliva CMV PCR test results. Of these 3 newborns, 2 had positive results on the confirmatory test (for 1 of them the confirmatory test was not performed until the infant was 10 weeks old), and 1 had a negative result on the confirmatory test. Three additional newborns with congenital CMV infection were tested because of clinical indications (1 for ventriculomegaly on prenatal ultrasound and 2 for CMV infection of the mother). Results of audiology follow-up were available for 149 (87.1%) of the 171 newborns who failed newborn hearing screening; 127 (85.2%) had normal results.

Conclusion: Our targeted screening program for congenital CMV infection had a low yield. Consideration should be given to other strategies for identifying children at risk of hearing loss as a result of congenital CMV infection.

Keywords: congenital CMV screening; failed newborn hearing screen; newborns.

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Figures

Figure 1.
Figure 1.
Targeted newborn screening protocol for cytomegalovirus at Yale-New Haven Health System. Abbreviations: CMV, cytomegalovirus; PCR, polymerase chain reaction.
Figure 2.
Figure 2.
Results of the targeted cytomegalovirus screening program. Abbreviations: CMV, cytomegalovirus; PICU, pediatric intensive care unit.
See this image and copyright information in PMC

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