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Comment
. 2018 Mar;8(3):262.
doi: 10.1158/2159-8290.CD-RW2018-015. Epub 2018 Jan 26.

Enhancer-Driven Gene Expression Changes Facilitate Metastasis

No authors listed
Comment

Enhancer-Driven Gene Expression Changes Facilitate Metastasis

No authors listed. Cancer Discov. 2018 Mar.

Abstract

Altered enhancer activity allows for dynamic gene expression to promote osteosarcoma metastasis.

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Comment on

  • Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.
    Morrow JJ, Bayles I, Funnell APW, Miller TE, Saiakhova A, Lizardo MM, Bartels CF, Kapteijn MY, Hung S, Mendoza A, Dhillon G, Chee DR, Myers JT, Allen F, Gambarotti M, Righi A, DiFeo A, Rubin BP, Huang AY, Meltzer PS, Helman LJ, Picci P, Versteeg HH, Stamatoyannopoulos JA, Khanna C, Scacheri PC. Morrow JJ, et al. Nat Med. 2018 Feb;24(2):176-185. doi: 10.1038/nm.4475. Epub 2018 Jan 15. Nat Med. 2018. PMID: 29334376 Free PMC article.

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