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Comment
. 2018 Mar;8(3):OF7.
doi: 10.1158/2159-8290.CD-RW2018-014. Epub 2018 Jan 26.

Chromosomal Instability Drives Metastasis Independent of Aneuploidy

No authors listed
Comment

Chromosomal Instability Drives Metastasis Independent of Aneuploidy

No authors listed. Cancer Discov. 2018 Mar.

Abstract

Chromosomal instability (CIN) promotes metastasis with little effect on primary tumor growth.

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  • Chromosomal instability drives metastasis through a cytosolic DNA response.
    Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, Genovese G, Venkatesan S, Birkbak NJ, McGranahan N, Lundquist M, LaPlant Q, Healey JH, Elemento O, Chung CH, Lee NY, Imielenski M, Nanjangud G, Pe'er D, Cleveland DW, Powell SN, Lammerding J, Swanton C, Cantley LC. Bakhoum SF, et al. Nature. 2018 Jan 25;553(7689):467-472. doi: 10.1038/nature25432. Epub 2018 Jan 17. Nature. 2018. PMID: 29342134 Free PMC article.

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