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Review
. 2018 Jan 26;7(1):4.
doi: 10.1186/s40169-018-0182-9.

Lipidomics unveils the complexity of the lipidome in metabolic diseases

Todd A Lydic  1 , Young-Hwa Goo  2
Affiliations
Review

Lipidomics unveils the complexity of the lipidome in metabolic diseases

Todd A Lydic et al. Clin Transl Med. .

Abstract

Dysregulation of lipid metabolism is responsible for pathologies of human diseases including metabolic diseases. Recent advances in lipidomics analysis allow for the targeted and untargeted identification of lipid species and for their quantification in normal and diseased conditions. Herein, this review provides a brief introduction to lipidomics, highlights its application to characterize the lipidome at the cellular and physiological levels under different biological conditions, and discusses the potential for the use of lipidomics in the discovery of biomarkers.

Keywords: Atherosclerosis; Lipid; Lipid droplet; Lipidome; Lipidomics; Lipoprotein; Mass spectrometry; Metabolic disease; Metabolism.

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Figures

Fig. 1
Fig. 1
Workflows of lipidomics. Lipids are extracted in organic solvents from various samples. Extracted lipids are either further separated by a chromatography or directly infused to mass-spectrometry. Peak analysis identified lipid species
Fig. 2
Fig. 2
Lipid distribution of animal cells. In animal cells, lipids are distributed in the plasma membrane (PM) and intracellular organelles. In all membranes, most commonly found lipids are phosphatidylcholines (PC) followed by phosphatidylethanolamines (PE). Cardiolipin is prevalently found in mitochondria. Extra FAs and free cholesterols are esterified in the ER and stored within cytosolic lipid droplet (LD) as triacylglycerol (TG) and cholesterol ester (CE) respectively. Lipid rafts are concentrated with cholesterols and sphingolipids
See this image and copyright information in PMC

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