Organelles: The Emerging Signalling Chart of Mitochondrial Dynamics
- PMID: 29374448
- DOI: 10.1016/j.cub.2017.11.040
Organelles: The Emerging Signalling Chart of Mitochondrial Dynamics
Abstract
Many molecular and functional details of single events in mitochondrial dynamics have been reported, but little is known about their coordination. A recent study describes how cellular Ca2+ signals, via remodelling the actin cytoskeleton, synchronise the formation of endoplasmic reticulum-mitochondria contacts with inner and outer mitochondrial membrane fission.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Comment on
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INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division.J Cell Biol. 2018 Jan 2;217(1):251-268. doi: 10.1083/jcb.201709111. Epub 2017 Nov 15. J Cell Biol. 2018. PMID: 29142021 Free PMC article.
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