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Comment
. 2018 Jan 22;28(2):R83-R86.
doi: 10.1016/j.cub.2017.11.059.

Antigen Presentation: Visualizing the MHC Class I Peptide-Loading Bottleneck

Meindert Lamers  1 , Ilana Berlin  1 , Jacques Neefjes  2
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Antigen Presentation: Visualizing the MHC Class I Peptide-Loading Bottleneck

Meindert Lamers et al. Curr Biol. .
Free article

Abstract

The peptide-loading complex is a bottleneck in antigen presentation by major histocompatibility complex (MHC) class I molecules. While the structures of its individual components were known, the recent report of the 7.2 Å structure of the entire complex now fits them into their functional context, explaining this monumental step in antigen acquisition by MHC class I molecules.

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