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Review
. 2018 Jan 16:7:58.
doi: 10.12688/f1000research.11906.1. eCollection 2018.

Recent advances in understanding and managing aortic stenosis

Mathias Van Hemelrijck  1 , Maurizio Taramasso  1 , Carlotta De Carlo  1 , Shingo Kuwata  1 , Evelyn Regar  1 , Fabian Nietlispach  2 , Adolfo Ferrero  1 , Alberto Weber  1 , Francesco Maisano  1
Affiliations
Review

Recent advances in understanding and managing aortic stenosis

Mathias Van Hemelrijck et al. F1000Res. .

Abstract

Over the last few years, treatment of severe symptomatic aortic stenosis in high-risk patients has drastically changed to adopt a less-invasive approach. Transcatheter aortic valve implantation (TAVI) has been developed as a very reproducible and safe procedure, as shown in many trials. When compared to surgery, TAVI has produced superior, or at least comparable, results, and thus a trend to broaden treatment indications to lower-risk patients has erupted as a natural consequence, even though there is a lack of long-term evidence. In this review, we summarize and underline aspects that still remain unanswered that are compulsory if we want to enhance our understanding of this disease.

Keywords: TAVI; aortic stenosis; surgical risk.

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Conflict of interest statement

Competing interests: Francesco Maisano is a consultant for Medtronic, St Jude Medical, Abbott Vascular, and Valtechcardio; receives royalties from Edwards Lifesciences; and is cofounder of 4Tech Cardio, AFfix, and Transseptal Solutions. Fabian Nietlispach is a consultant for Edwards Lifescience, St Jude Medical, and Medtronic. Maurizio Taramasso is a consultant for Abbott Vascular and 4tech. All other authors declare that they have no competing interests.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. SURTAVI Outcomes.
( a) Confirmation of the non-inferiority margin for TAVI. ( b) Time-to-event for death from any cause or disabling stroke. ( c) Time-to-death from any cause. ( d) Time-to-disabling stroke. From Reardon et al., 2017 . Reprinted with permission from Massachusetts Medical Society.
Figure 2.
Figure 2.. PARTNER 2 Trial Outcomes.
( a) Time-to-event for death from any cause or disabling stroke in the intention-to-treat population, ( b) in the as-treated population, ( c) in the transfemoral-access group in the intention to treat, ( d) and in the as-treated analysis. From Leon et al., 2016 . Reprinted with permission from Massachusetts Medical Society.
See this image and copyright information in PMC

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