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Observational Study
. 2017:2017:3793868.
doi: 10.1155/2017/3793868. Epub 2017 Dec 10.

Predictors of Insulin Resistance in Children versus Adolescents with Obesity

Yvette E Lentferink  1 , Marieke A J Elst  1 , Catherijne A J Knibbe  2 , Marja M J van der Vorst  1
Affiliations
Observational Study

Predictors of Insulin Resistance in Children versus Adolescents with Obesity

Yvette E Lentferink et al. J Obes. 2017.

Abstract

Introduction: Obesity is a risk factor to develop metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). Insulin resistance (IR) plays a major part in both. With increasing incidence of childhood obesity, this retrospective study aimed to identify predictors of IR in children/adolescents with obesity to optimize screening for IR.

Method: Patients aged ≥ 2-≤ 18 years with obesity (BMI-SDS > 2.3) were included. IR was defined as HOMA-IR ≥ 3.4, and MetS if ≥3 of the following criteria were present: waist circumference and blood pressure ≥ 95th age percentile, triglycerides ≥ 1.7 mmol/l, HDL < 1.03 mmol/l, and fasting plasma glucose ≥ 5.6 mmol/l.

Results: In total, 777 patients were included. Of the 306 children, 51, 38, and 0 were diagnosed with IR, MetS, and T2DM, respectively. Of the 471 adolescents, 223, 95, and 0 were diagnosed with IR, MetS, and T2DM, respectively. In the multivariable regression model, BMI-SDS, preterm birth, and Tanner stage were associated with IR in children (6.3 (95% CI 1.3-31.1), 5.4 (95% CI 1.4-20.5), 2.2 (95% CI 1.0-4.8)), and BMI-SDS and waist circumference in adolescents (4.0 (95% CI 1.7-9.2), 3.7 (95% CI 1.5-9.4)).

Conclusion: Different IR predictors were observed in children/adolescents with obesity. These predictors can be used to optimize screening for IR in pediatric populations.

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Figures

Figure 1
Figure 1
Flowchart of the study population.
See this image and copyright information in PMC

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