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Review
. 2018 Jan 18;11(1):143-149.
doi: 10.18240/ijo.2018.01.22. eCollection 2018.

The role of microglia in the progression of glaucomatous neurodegeneration- a review

Hui-Lan Zeng  1 , Jing-Ming Shi  1
Affiliations
Review

The role of microglia in the progression of glaucomatous neurodegeneration- a review

Hui-Lan Zeng et al. Int J Ophthalmol. .

Abstract

Glaucoma is a serious leading cause of irreversible blindness worldwide. Reducing intraocular pressure (IOP) does not always stop glaucomatous neurodegeneration and the optic nerve may continue to be damaged in the normal IOP. Microglial activity has been recognized to play essential roles in pathogenesis of the central nervous system (CNS) as well as retinal ganglion cell (RGC) survival. The relationship between the neurodegeneration and the microglia cells in glaucoma is very complicated and still remains unclear. In the present review, we summarize the recent studies of mechanisms of microglia in glaucoma neurodegeneration, which might provide new ways to treat glaucoma.

Keywords: glaucoma; microglia; neuroinflammation.

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Figures

Figure 1
Figure 1. Factors and cytokines related to microglia in glaucoma.
See this image and copyright information in PMC

References

    1. Rizzo MI, Greco A, De Virgilio A, Gallo A, Taverniti L, Fusconi M, Conte M, Pagliuca G, Turchetta R, de Vincentiis M. Glaucoma: recent advances in the involvement of autoimmunity. Immunol Res. 2017;65(1):207–217. - PubMed
    1. Mantravadi AV, Vadhar N. Glaucoma. Prim Care. 2015;42(3):437–449. - PubMed
    1. Kingman S. Glaucoma is second leading cause of blindness globally. Bull World Health Organ. 2004;82(11):887–888. - PMC - PubMed
    1. Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006;90(3):262–267. - PMC - PubMed
    1. Hernandez M, Rodriguez FD, Sharma SC, Vecino E. Immunohistochemical changes in rat retinas at various time periods of elevated intraocular pressure. Mol Vis. 2009;15(11):2696–2709. - PMC - PubMed