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. 2017:2017:3762194.
doi: 10.1155/2017/3762194. Epub 2017 Dec 11.

First-Line Helicobacter pylori Eradication in Patients with Chronic Kidney Diseases in Taiwan

Chih-Ming Liang  1 , Chien-Hua Chiu  2 , Hsing-Ming Wang  1 , Wei-Chen Tai  1 , Chih-Chien Yao  1 , Cheng-En Tsai  1 , Chung-Mou Kuo  1 , Yi-Chun Chiu  1 , Keng-Liang Wu  1 , Chen-Hsiang Lee  3 , Kai-Lung Tsai  4 , Chih-Fang Huang  5 , Seng-Kee Chuah  1
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First-Line Helicobacter pylori Eradication in Patients with Chronic Kidney Diseases in Taiwan

Chih-Ming Liang et al. Biomed Res Int. 2017.

Abstract

Aims: Patients with chronic kidney disease (CKD) and Helicobacter pylori (H. pylori) infection have a higher incidence of gastroduodenal diseases and therefore are recommended to receive eradication therapies. This study aimed to assess the efficacy of a 7-day standard triple therapy in patients with CKD (eGFR < 60 ml/min/1.73 m2) and to investigate the clinical factors influencing the success of eradication.

Methods: A total of 758 patients with H. pylori infection receiving a 7-day standard first-line triple therapy between January 1, 2013, and December 31, 2014, were recruited. Patients were divided into two groups: CKD group (N = 130) and non-CKD group (N = 628).

Results: The eradication rates attained by the CKD and non-CKD groups were 85.4% and 85.7%, respectively, in the per-protocol analysis (p = 0.933). The eradication rate in CKD stage 3 was 84.5% (82/97), in stage 4 was 88.2% (15/17), and in those who received hemodialysis was 87.5% (14/16). There were no significant differences in the various stages of CKD (p = 0.982). The adverse events were similar between the two groups (3.1% versus 4.6%, p = 0.433). Compliance between the two groups was good (100.0% versus 99.8%, p = 0.649). There was no significant clinical factor influencing the H. pylori eradication rate in the non-CKD and CKD groups.

Conclusions: This study suggests that the H. pylori eradication rate and adverse rate in patients with CKD are comparable to those of non-CKD patients.

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Disposition of patients.
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