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Review
. 2015 Sep 16;1(2):277-292.
doi: 10.3390/jof1020277.

Candida glabrata, Friend and Foe

Phyllix Tam  1 , Kirsten Gee  2 , Miryam Piechocinski  3 , Ian Macreadie  4
Affiliations
Review

Candida glabrata, Friend and Foe

Phyllix Tam et al. J Fungi (Basel). .

Abstract

Candida glabrata is mostly good, but, at times, it is an opportunistic pathogen. Previously known as Torulopsis glabrata, it enjoyed a good reputation and was even present in starter cultures. Its haploid genome and lack of mating made it an attractive challenge for yeast genetics studies. However, more recently it has become better known due to its character as an emerging cause of candidiasis, and for its resistance to multidrugs that are employed for candidiasis treatment. While now classified as Candida glabrata, it is still not a good fit and tends to stand alone as a very unique yeast. In terms of sequence, it is dissimilar to other Candida yeast and most similar to Saccharomyces cerevisiae.

Keywords: Torulopsis; antifungal resistance; azole; candidiasis; ergosterol; opportunistic pathogen; starter culture; statins; yeast.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The phylogenetic tree of some yeast species constructed by comparison of ERG11 sequences and using the tools available at http://www.candidagenome.org/.
Figure 2
Figure 2
Pathway for the synthesis of ergosterol, showing sites for inhibition by statins and azoles.
See this image and copyright information in PMC

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