Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jan 29;13(1):e0189115.
doi: 10.1371/journal.pone.0189115. eCollection 2018.

Effect of body mass index on diabetogenesis factors at a fixed fasting plasma glucose level

Jiunn-Diann Lin  1   2 , Chun-Hsien Hsu  3 , Chung-Ze Wu  1   2 , An-Tsz Hsieh  1 , Chang-Hsun Hsieh  4 , Yao-Jen Liang  5 , Yen-Lin Chen  6 , Dee Pei  7 , Jin-Biou Chang  8
Affiliations

Effect of body mass index on diabetogenesis factors at a fixed fasting plasma glucose level

Jiunn-Diann Lin et al. PLoS One. .

Erratum in

Abstract

Aim: The present study evaluated the relative influence of body mass index (BMI) on insulin resistance (IR), first-phase insulin secretion (FPIS), second-phase insulin secretion (SPIS), and glucose effectiveness (GE) at a fixed fasting plasma glucose level in an older ethnic Chinese population.

Methods: In total, 265 individuals aged 60 years with a fasting plasma glucose level of 5.56 mmol/L were enrolled. Participants had BMIs of 20.0-34.2 kg/m2. IR, FPIS, SPIS, and GE were estimated using our previously developed equations. Pearson correlation analysis was conducted to assess the correlations between the four diabetogenesis factors and BMI. A general linear model was used to determine the differences in the percentage of change among the four factor slopes against BMI.

Results: Significant correlations were observed between BMI and FPIS, SPIS, IR, and GE in both women and men, which were higher than those reported previously. In men, BMI had the most profound effect on SPIS, followed by IR, FPIS, and GE, whereas in women, the order was slightly different: IR, followed by FPIS, SPIS, and GE. Significant differences were observed among all these slopes, except for the slopes between FPIS and SPIS in women (p = 0.856) and IR and FPIS in men (p = 0.258).

Conclusions: The contribution of obesity to all diabetes factors, except GE, was higher than that reported previously. BMI had the most profound effect on insulin secretion in men and on IR in women in this 60-year-old cohort, suggesting that lifestyle modifications for obesity reduction in women remain the most important method for improving glucose metabolism and preventing future type 2 diabetes mellitus.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors declare that no competing interests exist.

Figures

Fig 1
Fig 1. Slopes of insulin resistance, first-phase and second-phase insulin secretions, and glucose effectiveness against the body mass indices of women.
Fig 2
Fig 2. Slopes of insulin resistance, first-phase and second-phase insulin secretions, and glucose effectiveness against the body mass indices of men.
See this image and copyright information in PMC

References

    1. DeFronzo RA, Tobin JD, Andres R (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. American Journal of Physiology 237: E214–223. doi: 10.1152/ajpendo.1979.237.3.E214 - DOI - PubMed
    1. Kahn SE (2003) The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia 46: 3–19. doi: 10.1007/s00125-002-1009-0 - DOI - PubMed
    1. Polonsky KS, Sturis J, Bell GI (1996) Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus—a genetically programmed failure of the beta cell to compensate for insulin resistance. The New England Journal of Medicine 334: 777–783. doi: 10.1056/NEJM199603213341207 - DOI - PubMed
    1. Caumo A, Luzi L (2004) First-phase insulin secretion: does it exist in real life? Considerations on shape and function. Am J Physiol Endocrinol Metab 287: E371–385. doi: 10.1152/ajpendo.00139.2003 - DOI - PubMed
    1. Pratley RE, Weyer C (2001) The role of impaired early insulin secretion in the pathogenesis of Type II diabetes mellitus. Diabetologia 44: 929–945. doi: 10.1007/s001250100580 - DOI - PubMed

Publication types