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Randomized Controlled Trial
. 2018 Jan 29;16(1):18.
doi: 10.1186/s12957-017-1307-0.

Outcome and prognostic factors in cervical cancer patients treated with surgery and concurrent chemoradiotherapy: a retrospective study

Yan-Mei Liu  1 , Ling-Qin Ni  1 , Sai-Sai Wang  1 , Qian-Ling Lv  2 , Wei-Jun Chen  1 , Shen-Peng Ying  3
Affiliations
Randomized Controlled Trial

Outcome and prognostic factors in cervical cancer patients treated with surgery and concurrent chemoradiotherapy: a retrospective study

Yan-Mei Liu et al. World J Surg Oncol. .

Abstract

Background: The objective of this study is to analyze the treatment outcome and secondary reactions in 98 patients with stage I-III cervical carcinoma who underwent postoperative radiotherapy.

Methods: From 2006 to 2014, 98 patients with stage I-III cervical carcinoma were treated with postoperative radiotherapy. The major histological type, found in 92.86% of the patients (91 cases), was squamous cell carcinoma. Patients were staged according to the 2002 TNM guidelines. The postoperative radiotherapy methods included two-field irradiation (16 patients, 16.32%), four-field box irradiation (16 patients, 16.32%), and intensity-modulated radiotherapy (IMRT; 66 patients, 67.36%). The survival rates were represented using Kaplan-Meier curves, and prognosis analyses were performed using Cox multivariate analyses.

Results: The 5-year overall survival and progression-free survival rates were 82.0 and 76.0%, respectively. Only one patient (1.02%) developed a grade 3 acute radiation enteritis, while grade 3 and 4 myelosuppression was noted in 17 patients (17.35%) and one patient (1.02%), respectively. Multivariate analyses showed that anemia before radiotherapy and tumor size were predictors of the OS (P = 0.008, P = 0.045) rates.

Conclusions: Postoperative radiotherapy for patients with risk factors of cervical cancer procured good efficacy levels with mild side effects. Anemia and tumor size were important OS predictors.

Keywords: Cervical carcinoma; Chemoradiotherapy; Postoperative radiotherapy; Prognosis.

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Conflict of interest statement

Ethics approval and consent to participate

This study was approved by the ethical committee of Tai Zhou Central Hospital.

Consent for publication

Written informed consent was obtained from the patient for publication of this report and the accompanying images.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Survival curves of overall and progression-free survival
Fig. 2
Fig. 2
Effect of anemia on overall survival (P = 0.00)
Fig. 3
Fig. 3
Effect of lymph node status on overall survival (P = 0.04)
Fig. 4
Fig. 4
Effect of tumor size on overall survival (P = 0.00) of patients
See this image and copyright information in PMC

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