Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Jan 29:2018:bcr2017221803.
doi: 10.1136/bcr-2017-221803.

Intravascular lymphoma presenting with postural hypotension

Catharine Pearce  1 , Suzy Hope  1   2 , Joseph Butchart  1
Affiliations
Case Reports

Intravascular lymphoma presenting with postural hypotension

Catharine Pearce et al. BMJ Case Rep. .

Abstract

An 84-year-old woman presented with severe postural hypotension. Further assessment revealed weight loss, fatigue and fever at night. On examination, she had bilateral skin lesions on the inner thighs and skin biopsy revealed intravascular high grade B cell lymphoma. This was successfully treated with curative chemotherapy. The cause of the postural hypotension in this case was felt likely to be autonomic neuropathy caused by neurovascular infiltration by intravascular lymphoma. Treatment of the lymphoma has resolved the postural hypotension, although some symptoms of postural instability persist.

Keywords: adrenal disorders; dermatology; geriatric medicine; haematology (incl blood transfusion).

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

References

    1. Lanier JB, Mote MB, Clay EC. Evaluation and management of orthostatic hypotension. Am Fam Physician 2011;84:527–36. - PubMed
    1. Ponzoni M, Ferreri AJ, Campo E, et al. . Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meeting. J Clin Oncol 2007;25:3168–73. 10.1200/JCO.2006.08.2313 - DOI - PubMed
    1. Del Paggio JC, Bradshaw S, Marcotte L. Disturbances in blood flow and ’medicine’s greatest imitator'. Intern Med J 2017;47:586–8. 10.1111/imj.13414 - DOI - PubMed
    1. Ferreri AJ, Campo E, Seymour JF, et al. . Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the ’cutaneous variant'. Br J Haematol 2004;127:173–83. 10.1111/j.1365-2141.2004.05177.x - DOI - PubMed
    1. Daniel SE, Rudge P, Scaravilli F. Malignant angioendotheliosis involving the nervous system: support for a lymphoid origin of the neoplastic cells. J Neurol Neurosurg Psychiatry 1987;50:1173–7. 10.1136/jnnp.50.9.1173 - DOI - PMC - PubMed

Publication types

MeSH terms