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Editorial
. 2018 Jan 30;137(5):504-507.
doi: 10.1161/CIRCULATIONAHA.117.031716.

Lymphangiogenesis in Chronic Rejection and Coronary Allograft Vasculopathy: An Emerging Diagnostic and Therapeutic Target?

H Scott Baldwin  1 , Stavros G Drakos  2
Affiliations
Editorial

Lymphangiogenesis in Chronic Rejection and Coronary Allograft Vasculopathy: An Emerging Diagnostic and Therapeutic Target?

H Scott Baldwin et al. Circulation. .
No abstract available

Keywords: Editorials; allografts; graft rejection; heart transplantation; lymphangiogenesis; lymphoscintigraphy.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr. Baldwin, none; Dr. Drakos, none.

Figures

Figure 1
Figure 1. Schematic representation of cardiac lymphatic response to injury.
Normal cardiac lymphatic flow is from endocardium to subepicardial collecting lymphatics. The chronic response of lymphatic vessels after transplantation is marked by proliferation and dilation of collecting lymphatics permitting greater egress of antigen presenting cells (APCs) from the donor heart to recipient draining lymph nodes. The subsequent immune response results in cardiac allograft vasculopathy (CAV). During the acute response to myocardial ischemia there is a robust lymphangiogenesis that facilitates repair of infarcted myocardium.
See this image and copyright information in PMC

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References

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