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. 2018 Jan;26(1):1-6.
doi: 10.1016/j.jsps.2017.11.007. Epub 2017 Nov 14.

Effect of combined gliclazide/metformin treatment on oxidative stress, lipid profile, and hepatorenal functions in type 2 diabetic patients

Mansour Alsharidah  1   2 , Metab Algeffari  3 , Abdel-Moneim Hafez Abdel-Moneim  1   4 , Mohamed Faisal Lutfi  1 , Haila Alshelowi  5
Affiliations

Effect of combined gliclazide/metformin treatment on oxidative stress, lipid profile, and hepatorenal functions in type 2 diabetic patients

Mansour Alsharidah et al. Saudi Pharm J. 2018 Jan.

Abstract

Background: Type 2 diabetes is a chronic condition that requires pharmacotherapy interventions. Metformin and gliclazide are widely used drugs in monotherapy. However, their complementary action made utilization of the combination of these drugs an appealing approach.

Aims: The study compared major therapeutic potentials of combined metformin/gliclazide treatment over metformin monotherapy based on the following parameters: oxidative stress, lipid profile, and hepatorenal functions.

Subjects and methods: This is a comparative study was conducted from March 2015 to March 2016. The study screened 80 type 2 diabetic patients, of which 40 patients underwent combined metformin + gliclazide therapy (500 mg BD + 80 mg OD, respectively). The other 40 were matched for age and duration of diabetes mellitus with the previous group and received metformin monotherapy (500 mg BD). The levels of fasting blood glucose (FBG), total glycated hemoglobin (HbA1c), lipid peroxidation, total antioxidant capacity, serum creatinine, aspartate and alanine transaminases, total cholesterol, triglycerides, high-density lipoproteins, and low-density lipoproteins were measured according to the standard methods.

Results: Oxidative stress, lipid profile, and hepatorenal functions were comparable in patients of both groups. However, patients on metformin treatment showed significantly lower levels of FBG [7.61 (6.70-8.89) mmol/L vs. 9.00 (7.30-10.68) mmol/L; P = .022] and HBA1c [7.00 (6.40-7.65)% vs. 8.20 (7.20-9.75)%; P < .001] compared to those on combined therapy.

Conclusion: Oxidative stress, lipids profile, and hepatorenal functions were not different in patients who were on combined metformin/gliclazide therapy and compared to those metformin alone. In contrast, glycemic control was poor in the diabetic patients undergoing combined therapy.

Keywords: Diabetes mellitus; Gliclazide; Glucose; Lipids; Metformin; Oxidative stress.

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Figures

Fig. 1
Fig. 1
Boxplot showing indicators of glycemic control in patients on mono and combined anti-diabetic therapy.
Fig. 2
Fig. 2
Boxplot showing oxidative stress in patients on mono and combined anti-diabetic therapy.
Fig. 3
Fig. 3
Boxplot showing lipid profile in patients on mono and combined anti-diabetic therapy.
Fig. 4
Fig. 4
Boxplot showing hepatorenal functions in patients on mono and combined anti-diabetic therapy.
See this image and copyright information in PMC

References

    1. Ahad A., Mujeeb M., Ahsan H., Siddiqui W.A. 10. Prophylactic effect of baicalein against renal dysfunction in type 2 diabetic rats. Biochimie. 2014;106:101–110. - PubMed
    1. Al-Gareeb A.I., Alrubai H.F., Suliaman S.M. Effects of gliclazide add on metformin on serum omentin-1 levels in patients with type 2 diabetes mellitus. Indian J. Endocrinol. Metab. 2016;20:195–198. - PMC - PubMed
    1. Allain C.C., Poon L.S., Chan C.S., Richmond W., Fu P.C. 28. Enzymatic determination of total serum cholesterol. Clin. Chem. 1974;20:470–475. - PubMed
    1. Asmat U., Abad K., Ismail K. Diabetes mellitus and oxidative stress – a concise review. Saudi Pharm. J. SPJ Off. Publ. Saudi Pharm. Soc. 2016;24:547–553. - PMC - PubMed
    1. Barham D., Trinder P. 22. An improved colour reagent for the determination of blood glucose by the oxidase system. Analyst. 1972;97:142–145. - PubMed

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