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. 2018 Jan 17:19:45-48.
doi: 10.1016/j.mmcr.2017.11.001. eCollection 2018 Mar.

Histoplasmosis: An oral malignancy-like clinical picture

Tomasz Chroboczek  1 , Julie Dufour  1 , Alain Renaux  2 , Christine Aznar  3   4 , Magalie Demar  3   4 , Pierre Couppie  1   4 , Antoine Adenis  4   5
Affiliations

Histoplasmosis: An oral malignancy-like clinical picture

Tomasz Chroboczek et al. Med Mycol Case Rep. .

Abstract

HIV-associated histoplasmosis is mainly misdiagnosed for granulomatous diseases, such as tuberculosis. Nonetheless, malignancy-like lesions have been reported sporadically in HIV-infected patients. Although the main reported lesions are erosive or ulcerated, here a rare case of oral tumor is reported. This case raises the awareness of this presentation, and the importance of accurate identification in the laboratory. Performing systematic specific stains for fungal elements and culture on tissue samples ensures accurate differential diagnosis.

Keywords: Differential diagnosis; HIV; Histoplasma capsulatum; Histoplasmosis; Oral.

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Figures

Fig. 1
Fig. 1
Oral examination upon hospital admission.
Fig. 2
Fig. 2
Chest X-Ray upon hospital admission.
Fig. 3
Fig. 3
Computed tomography of the pharyngeal region upon hospital admission (sagittal section).
Fig. 4
Fig. 4
Computed tomography of the thoracic region upon hospital admission (horizontal sections).
Fig. 5
Fig. 5
LEFT: Tongue biopsy with Histoplasma capsulatum yeasts colored in fuchsia (Periodic-Acid-Schiff, ×40), RIGHT: Tongue biopsy with Histoplasma capsulatum yeasts colored in black (Gommori-Grocott, silver staining, ×20).
Fig. 6
Fig. 6
Tissue smears with cells of the base of the tongue, showing intra cellular yeasts of Histoplasma Capsulatum (May-Grumwald-Giemsa, ×100).
Fig. 7
Fig. 7
Oral examination showing a marked decreased of the lesion after one week of antifungal therapy with itraconazole.
See this image and copyright information in PMC

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