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Review
. 2018 Feb 14;16(7):1050-1064.
doi: 10.1039/c7ob02978k.

gem-Diborylalkanes: recent advances in their preparation, transformation and application

Affiliations
Review

gem-Diborylalkanes: recent advances in their preparation, transformation and application

Rajender Nallagonda et al. Org Biomol Chem. .

Abstract

Recently, gem-diborylalkanes have attracted much attention as versatile building blocks and fundamental intermediates in organic synthesis, because they enable multiple C-C bond construction and further transformation at C-B bonds. Importantly, gem-diborylalkanes can be utilised as bisnucleophilic partners in a variety of chemo-selective C-C bond-forming reactions. This review describes recent developments in synthesising gem-diborylalkanes in complex molecules along with their chemical transformation. In the first part of the review the different synthetic approaches used to synthesise gem-diborylalkanes are described. In the second part, an overview of the chemoselective transformation of gem-diborylalkanes into various functionalized materials is discussed along with one-carbon homologation of diborylmethane via a selective uni- and bidirectional method.

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