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. 2017 Nov;96(47):e8906.
doi: 10.1097/MD.0000000000008906.

Wendan decoction for primary insomnia: Protocol for a systematic review and meta-analysis

Xia Yan  1 , Yuanping Wang, Xiaohui Li, Ziqin Li, Yu Zhang, Xiaoli Cai, Dawei Wang
Affiliations

Wendan decoction for primary insomnia: Protocol for a systematic review and meta-analysis

Xia Yan et al. Medicine (Baltimore). 2017 Nov.

Abstract

Background: Insomnia is a widespread complaint in the general population. Wendan decoction has been widely applied in the treatment of primary insomnia. However, to our knowledge, there has been no systematic review or meta-analysis of randomized controlled trails regarding the effectiveness of this treatment. Here, we provide a protocol to evaluate the efficacy and safety of Wendan decoction for primary insomnia.

Methods and analysis: Relevant randomized controlled trials in 5 English databases [EMBASE, the Cochrane Central Register of Controlled Trials (Cochrane Library), PubMed, the Allied and Complementary Medicine Databases (AMED), and the Cumulative Index to Nursing and Allied Health Literature (CINAHL)], 4 Chinese databases [Chinese Biomedical Literature Database (CBM), Chinese Medical Current Content (CMCC), China National Knowledge Infrastructure (CNKI), and Wanfang Database] will be comprehensively searched by 2 researchers in October 2017. The therapeutic effects according to the Pittsburgh Sleep Quality Index (PSQI) will be accepted as the primary outcomes. We will use RevMan V.5.3 software as well to compute the data synthesis carefully when a metaanalysis is allowed.

Results: This study will provide a high-quality synthesis of current evidence of Wendan decoction for primary insomnia from several aspects including PSQI, the total scores of the Insomnia Severity Index (ISI), syndrome according to standards for assessing Traditional Chinese medicine and adverse events.

Conclusion: The conclusion of our systematic review will provide evidence to judge whether Wendan decoction is an effective intervention for patient with primary insomnia.

Ethics and dissemination: The outcomes of this systematic review will offer implications of the use of Wendan decoction treatment for primary insomnia patients. This knowledge informing recommendations will be provided by researchers who are interested in the treatment of primary insomnia. The results of this study will be disseminated through presentation at a conference and publication of the data in a peer-reviewed journal.

Prospero registration number: PROSPERO CRD 42017065664.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flow diagram of study selection process.
Figure 2
Figure 2
Flow diagram of the systematic review and meta-analysis.
See this image and copyright information in PMC

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References

    1. Ohayon MM. Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev 2002;6:97–111. - PubMed
    1. Janson C, Lindberg E, Gislason T, et al. Insomnia in men-a 10-year prospective population based study. Sleep 2001;24:425–30. - PubMed
    1. Laugsand LE, Strand LB, Vatten LJ, et al. Insomnia symptoms and risk for unintentional fatal injuries: the HUNT Study. Sleep 2014;37:1777–86. - PMC - PubMed
    1. Javaheri S, Redline S. Insomnia and risk of cardiovascular disease. Chest 2017;152:435–44. - PMC - PubMed
    1. Sofi F, Cesari F, Casini A, et al. Insomnia and risk of cardiovascular disease: a meta-analysis. Eur J Prev Cardiol 2014;21:57–64. - PubMed

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