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Randomized Controlled Trial
. 2018 Jan 29;10(2):149.
doi: 10.3390/nu10020149.

The Influence of Pre-Exercise Glucose versus Fructose Ingestion on Subsequent Postprandial Lipemia

Tsung-Jen Yang  1 , Chih-Hui Chiu  2 , Mei-Hui Tseng  3 , Cheng-Kang Chang  4 , Ching-Lin Wu  5
Affiliations
Randomized Controlled Trial

The Influence of Pre-Exercise Glucose versus Fructose Ingestion on Subsequent Postprandial Lipemia

Tsung-Jen Yang et al. Nutrients. .

Abstract

Ingestion of low glycemic index (LGI) carbohydrate (CHO) before exercise induced less insulin response and higher fat oxidation than that of high GI (HGI) CHO during subsequent exercise. However, the effect on the subsequent postprandial lipid profile is still unclear. Therefore, the aim of this study was to investigate ingestion of CHO drinks with different GI using fructose and glucose before endurance exercise on the subsequent postprandial lipid profile. Eight healthy active males completed two experimental trials in randomized double-blind cross-over design. All participants ingested 500 mL CHO (75 g) solution either fructose (F) or glucose (G) before running on the treadmill at 60% VO₂max for 1 h. Participants were asked to take an oral fat tolerance test (OFTT) immediately after the exercise. Blood samples were obtained for plasma and serum analysis. The F trial was significantly lower than the G trial in TG total area under the curve (AUC; 9.97 ± 3.64 vs. 10.91 ± 3.56 mmol × 6 h/L; p = 0.033) and incremental AUC (6.57 ± 2.46 vs. 7.14 ± 2.64 mmol/L × 6 h, p = 0.004). The current data suggested that a pre-exercise fructose drink showed a lower postprandial lipemia than a glucose drink after the subsequent high-fat meal.

Keywords: fat oxidation; glycemic index; high-density lipoprotein; oral fat tolerance test; triacylglycerol.

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Conflict of interest statement

The authors declare no conflict of interest. The funding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Triacylglycerol (TG) incremental area under the curve (a) and TG area under the curve (b) in 6 h and postprandial TG concentration over 6 h (c). # F was significantly lower than G (p = 0.004). * F was significantly lower than G (p = 0.033).
Figure 2
Figure 2
Serum insulin concentrations (a) and plasma glucose concentrations (b) during the 6 h postprandial period, p < 0.05.
Figure 3
Figure 3
Plasma NEFA concentrations (a); and glycerol concentrations (b) during the 6 h postprandial period. NEFA: non-esterfied fatty acid.
Figure 4
Figure 4
Plasma HDL-C concentrations during the 6 h postprandial period.
See this image and copyright information in PMC

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