Competing interests: Dr. Reaume has been an advisor for Astellas, Pfizer, and Roche; has received grants/honoraria from AstraZeneca, Ferring, Merck, Novartis, and Sanofi; and has participated in clinical trials supported by Novartis, Pfizer, and Roche. Dr. Basappa has been an advisor for Astellas, AstraZeneca, BI, BMS, Janssen, Novartis, and Pfizer; and has received honoraria from Astellas, BMS, Janssen, Novartis, and Pfizer. Dr. Wood has been an advisor for Astellas, BMS, Novartis, and Pfizer. Dr. Kapoor has been an advisor for and participated in clinical trials supported by Amgen, Astellas, Janssen, GSK, Novartis, Pfizer, and Sanofi. Dr. Bjarnason has received grants and honoraria from BMS, Merck, Novartis, and Pfizer. Dr. Blais has received consulting honoraria from BMS, Merck, Novartis, Pfizer, and Roche. Dr. Canil has been an advisor for Astellas, Bayer, BMS, Esai, Merck, Pfizer, Roche, and Sanofi; received an educational grant from Pfizer; and participated in clinical trials supported by AstraZeneca, Bayer, Janssen, Medivation, and Roche. Dr. Cheung has received investigator-initiated grants from Abbvie, Aventis, Pfizer and Sanofi. Dr. Conter has been an advisor for Novartis and Pfizer. Dr. Hotte has been an advisor for AstraZeneca, BMS, Merck, and Pfizer; and has participated in clinical trials supported by AstraZeneca, BMS, Merck, and Takeda. Dr. Jewett has been an advisor for Pfizer and Theralase; a consultant for Olympus, Pfizer, and Theralase; and holds investments in Theralase. Dr. Karakiewicz has been an advisor for Pfizer; has received payment for advisory board presentations from AbbVie, Astellas, Ferring, Janssen, and Pfizer; and has received a research grant from Pfizer. Dr. So has been a speaker for Amgen, Astellas, and Janssen. Dr. Soulières has been an advisor for Novartis and Pfizer; and has participated in clinical trials supported by Merck and Pfizer. Dr. Venner has been an advisor for Astellas, Novartis, Pfizer, and Sanofi; has received speaker honoraria from Astellas; and has participated in clinical trials supported by Astellas, BMS, and Exelixis. Dr. Violette has been an advisor for Janssen and a speaker for Astellas, Janssen, Pfizer, and Sanofi. Dr. Zalewski has participated in clinical trials supported by BMS, Janssen, Pfizer, and Roche. Dr. North has been an advisor for Astellas; received honoraria from Astellas, AstraZeneca, Janssen, Merck, Novartis, Pfizer, Roche, and Sanofi; and participated in clinical trials supported by Astellas, Roche, and Sanofi. The remaining authors report no competing personal or financial interests.