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. 2018 Jan 30;8(1):1849.
doi: 10.1038/s41598-018-20133-6.

Frequency of EBV associated classical Hodgkin lymphoma decreases over a 54-year period in a Brazilian population

Antonio Hugo Jose Froes Marques Campos  1 , Adriana Moreira  2 , Karina Braga Ribeiro  3 , Roberto Pinto Paes  4 , Maria Claudia Zerbini  5 , Vera Aldred  4 , Carmino Antonio de Souza  6 , Cristovam Scapulatempo Neto  7   8 , Fernando Augusto Soares  2   9 , Jose Vassallo  2   10
Affiliations

Frequency of EBV associated classical Hodgkin lymphoma decreases over a 54-year period in a Brazilian population

Antonio Hugo Jose Froes Marques Campos et al. Sci Rep. .

Abstract

The epidemiology of classical Hodgkin lymphoma varies significantly in populations with different socioeconomic conditions. Among other changes, improvement in such conditions leads to a reduction in the association with EBV infection and predominance of the nodular sclerosis subtype. This study provides an overview of the epidemiology of 817 cases of classical Hodgkin lymphoma diagnosed in five reference hospitals of the State of Sao Paulo, Brazil, over 54 years (1954-2008). The cases were distributed in 3 periods (1954-1979; 1980-1999; and 2000-2008). EBV-positive cases decreased from 87% to 46%. In children and adolescents (<15 years) and in young adults (15-45 years), EBV-positive cases decreased respectively from 96% to 64%, and from 85% to 32%. The percentage of male patients declined from 80% to 58%. In older patients (>45 years), the decrease in EBV infection was not significant. Nodular Sclerosis was the most common subtype in all periods. These results support the hypothesis that, in the Brazilian State of Sao Paulo, classical Hodgkin lymphoma has changed and now shows characteristics consistent with Pattern III observed in populations that experienced a similar socioeconomic transition.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Gender distribution of patients diagnosed with classical Hodgkin lymphoma over 54 years. (A) Whole cohort; (B) Patients under 15 years; (C) Patients between 15–44 years; (D) Patients aged 45 years and older. Cochran-Armitage test for trend.
Figure 2
Figure 2
Prevalence of EBV-positive classical Hodgkin lymphoma over 54 years. Jointpoint trend analysis.
Figure 3
Figure 3
Frequency of EBV-associated classical Hodgkin lymphoma over 54 years. (A) Whole cohort; (B) Patients under 15 years; (C) Patients between 15–44 years; (D) Patients aged 45 years and older. Cochran-Armitage test for trend.
Figure 4
Figure 4
Frequency of EBV-associated classical Hodgkin lymphoma over 54 years, according to gender (A) males; (B) Females. Cochran-Armitage test for trend.
Figure 5
Figure 5
Frequency of EBV-associated classical Hodgkni lymphoma over 54 years, according to Ann Arbor Stage ((A)-Stage I-II; (B)-Stage III-IV). Cochran-Armitage test for trend.
Figure 6
Figure 6
Frequency of EBV-associated classical Hodgkin lymphoma over 54 years, according to histological type (A) mixed cellulatiry; (B) nodular sclerosis. Cochran-Armitage test for trend.
See this image and copyright information in PMC

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