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Review
. 2018 Mar;17(1):13-18.
doi: 10.1007/s12663-016-0988-1. Epub 2016 Dec 16.

Bone regeneration with recombinant human bone morphogenetic protein 2: a systematic review

Jannice de Queiroz Fernandes  1 , Valthierre Nunes de Lima  2 , João Paulo Bonardi  2 , Osvaldo Magro Filho  2 , Sormani Bento Fernandes Queiroz  1
Affiliations
Review

Bone regeneration with recombinant human bone morphogenetic protein 2: a systematic review

Jannice de Queiroz Fernandes et al. J Maxillofac Oral Surg. 2018 Mar.

Abstract

Aim: The aim of this work was to perform a systematic literature review on the clinical application of rhBMP-2 in bone reconstruction prior to placing implants.

Materials and methods: A PUBMED search was made about the subject and nine clinical trials were selected according to strict inclusion criteria.

Results: Overall success rates of bone regeneration with rhBMP-2 was 81.4% and success of implants placed was 87.4%. Most frequent adverse events were pain, edema and erythema.

Conclusion: It was concluded that the treatment with rhBMP-2 foi satisfactory in most cases and the placement of dental implants in the bone regenerated with rhBMP-2 is feasible.

Keywords: Bone graft; Bone morphogenetic protein 2; Dental implants; Rehabilitation.

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Conflict of interest statement

Compliance with Ethical StandardsAuthor Jannice de Queiroz Fernandes declares that she has no conflict of interest. Author Valthierre Nunes de Lima declares that he has no conflict of interest. Author João Paulo Bonardi declares that he has no conflict of interest. Author Osvaldo Magro Filho declares that he has no conflict of interest. Author Sormani Bento Fernandes Queiroz declares that he has no conflict of interest.This article does not contain any studies with human participants or animals performed by any of the authors.

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