Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Dec 4;8(70):115691-115700.
doi: 10.18632/oncotarget.22929. eCollection 2017 Dec 29.

Meta-analysis of the correlation between Helicobacter pylori infection and autoimmune thyroid diseases

Yi Hou #  1   2 , Wen Sun #  1 , Chengfei Zhang  1   2 , Tieshan Wang  3 , Xuan Guo  1   2 , Lili Wu  3 , Lingling Qin  4 , Tonghua Liu  1
Affiliations

Meta-analysis of the correlation between Helicobacter pylori infection and autoimmune thyroid diseases

Yi Hou et al. Oncotarget. .

Abstract

Objective: This study presents a systematic meta-analysis of the correlation between Helicobacter pylori (H. pylori) infection and autoimmune thyroid diseases (AITD).

Materials and methods: Fifteen articles including 3,046 cases were selected (1,716 observational and 1,330 control cases). These data were analyzed using Stata12.0 meta-analysis software.

Results: H. pylori infection was positively correlated with the occurrence of AITD (OR = 2.25, 95% CI: 1.72-2.93). Infection with H. pylori strains positive for the cytotoxin-associated gene A (CagA) were positively correlated with AITD (OR = 1.99, 95% CI: 1.07-3.70). There was no significant difference between infections detected using enzyme-linked immunosorbent assay (ELISA) and other methods (χ2 = 2.151, p = 0.143). Patients with Grave's disease (GD) and Hashimoto's thyroiditis (HT) were more susceptible to H. pylori infection (GD: OR = 2.78, 95% CI: 1.68-4.61; HT: OR = 2.16, 95% CI: 1.44-3.23), while the rate of H. pylori infection did not differ between GD and HT (χ2 = 3.113, p = 0.078).

Conclusions: H. pylori infection correlated with GD and HT, and the eradication of H. pylori infection could reduce thyroid autoantibodies.

Keywords: AITD; helicobacter pylori infection; meta-analysis.

PubMed Disclaimer

Conflict of interest statement

CONFLICTS OF INTEREST All authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. Flow chart of systematic literature review
Figure 2
Figure 2. Funnel plot analysis of H. pylori infection and autoimmune thyroid diseases
Figure 3
Figure 3. Correlation analysis of H. pylori infection with AITD by different detection methods
Note: AITD, autoimmune thyroid diseases; Elisa, enzyme-linked immunosorbent assay; Others, other methods for detecting H. pylori infection; NR, no reported.
Figure 4
Figure 4. Correlation analysis of H. pylori infection with GD and HT
Note: GD, Grave’s disease; HT, Hashimoto’s thyroiditis.
Figure 5
Figure 5. Correlation analysis of infection with a CagA-positive strain of H. pylori, and AITD
See this image and copyright information in PMC

References

    1. Jiyao W. Internal medicine. second. People’s medical publishing house; 2010. pp. 942–963.
    1. Baloch Z, Carayon P, Conte-Devolx B, Demers LM, Feldt-Rasmussen U, Henry JF, LiVosli VA, Niccoli-Sire P, John R, Ruf J, Smyth PP, Spencer CA, Stockigt JR, Guidelines Committee, National Academy of Clinical Biochemistry Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid. 2003;13:3–126. - PubMed
    1. Balázs C. The role of hereditary and environmental factors in autoimmune thyroid diseases. Article in Hungarian. Orv Hetil. 2012;153:1013–22. - PubMed
    1. Yamazaki K, Tanigawa K, Suzuki K, Yamada E, Yamada T, Takano K, Obara T, Sato K. Iodide-induced chemokines and genes related to immunological function in cultured human thyroid follicles in the presence of thyrotropin. Thyroid. 2010;20:67–76. - PubMed
    1. Gangi E, Kapatral V, El-Azami El-Idrissi M, Martinez O, Prabhakar BS. Characterization of a recombinant Yersinia enterocolitica lipoprotein; implications for its role in autoimmune response against thyrotropin receptor. Autoimmunity. 2004;37:515–520. - PubMed

LinkOut - more resources