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Review
. 2019 Jan;116(1):14-17.
doi: 10.1007/s00347-018-0649-5.

[Visual recovery as the target for glaucoma]

[Article in German]
V Chrysostomou  1   2 , R J Hatch  1   2 , T Colgan  1   2 , J P Paul  1   2 , P van Wijngaarden  1   2 , I Trounce  1   2 , M I G Lopez Sanchez  1   2 , K Bell  3 , F Grus  3 , J G Crowston  4   5
Affiliations
Review

[Visual recovery as the target for glaucoma]

[Article in German]
V Chrysostomou et al. Ophthalmologe. 2019 Jan.

Abstract

Background: Visual recovery is an established but poorly studied phenomenon in glaucoma.

Objective: To provide insights into functional recovery of retinal ganglion cells (RGCs) with a view to providing information on the development of forms of treatment that improve RGC function after injury.

Method: A model of recoverable RGC function in the mouse eye, induced by short-term elevation of intraocular pressure (IOP).

Results: The RGCs manifest near complete functional recovery after a prolonged period of dysfunction following acute IOP elevation. Increasing age and a high fat diet were subsequently found to impair recovery, whereas exercise substantially improved recovery such that older mice recovered in a similar way to young mice.

Conclusion: Injured RGCs have the capacity to restore function after periods of functional impairment. Therapies that specifically target injured RGCs and enhance their capacity to recover function may provide a new approach for treating glaucoma.

Keywords: Aging; Mouse models; Retinal ganglion cell; Vision; Visual field.

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