Prognostic factors for soft tissue sarcoma patients with lung metastases only who are receiving first-line chemotherapy: An exploratory, retrospective analysis of the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG)

Abstract

The prognosis of adult soft tissue sarcoma (STS) patients with metastases is generally poor. As little is known about the impact of the involvement of different metastatic sites and the extent of pulmonary lesions on the outcome for patients receiving first-line chemotherapy, we aimed to establish prognostic factors for STS patients with lung metastases only. A retrospective, exploratory analysis was performed on 2,913 metastatic STS patients who received first-line chemotherapy. Detailed information from 580 patients who had lung metastases only, was used for prognostic factor analysis. Patients with lung metastases only were more often asymptomatic and had undergone complete primary tumor resection more frequently compared to patients with additional metastases outside the lung or without lung metastases. For extremity STS, the incidence of lung metastases only was much higher compared to non-extremity STS. Lung involvement only was an independent favorable prognostic factor for overall survival (OS) with regard to metastatic site. Within this subgroup, in a multivariate model, other factors associated with improved OS included: good performance status (PS), no progression at primary site, low histological grade, younger age, long interval between initial diagnosis and trial registration, and smaller diameter of the largest lung lesion. This unique analysis on prognostic factors in STS patients with lung metastases confirms well-known patient factors (such as age and PS), and tumor characteristics (including tumor grade, interval between primary diagnosis, and metastases), but also identifies diameter of the largest lung lesion as a new prognostic factor. Knowledge about these factors may support decision-making within multidisciplinary tumor boards.

Keywords: EORTC; lung metastases; prognostic factors; soft tissue sarcoma.

Figure 1

Overall survival (a) and progression free survival (b) of 2,913 metastatic sarcoma patients receiving first‐line chemotherapy with lung lesions only, other lesions only, or both types of lesions. [Color figure can be viewed at wileyonlinelibrary.com]

Figure 2

Overall survival in 580 sarcoma patients with lung metastases only by type of chemotherapy treatment (a), performance status (b), histopathological grading (c), time between the initial diagnosis and start of treatment (d), and by diameter of the largest lung lesion (e). [Color figure can be viewed at wileyonlinelibrary.com]

Figure 3

Progression free survival in 580 sarcoma patients with lung lesions only by type of chemotherapy treatment (a), performance status (b), number of lung lesions (c), diameter of the largest lung lesion (d), and time between the initial diagnosis and start of treatment (e). [Color figure can be viewed at wileyonlinelibrary.com]