The Impact of Underpowered Studies on Clinical Trial Results

Affiliations

¹ From the Northwest Clinical Research Center, Bellevue, Wash.; the Department of Psychiatry, Duke University School of Medicine, Durham, N.C.; and the Department of Psychiatry and Human Behavior, Brown University, Providence, R.I.

Comment

Arif Khan et al. Am J Psychiatry. 2018.

. 2018 Feb 1;175(2):188.

doi: 10.1176/appi.ajp.2017.17091016.

¹ From the Northwest Clinical Research Center, Bellevue, Wash.; the Department of Psychiatry, Duke University School of Medicine, Durham, N.C.; and the Department of Psychiatry and Human Behavior, Brown University, Providence, R.I.

No abstract available

Keywords: Clinical Drug Studies; Clinical Trials; Other Aspects Of Psychopharmacology; Statistical Power.

Comment in

The Importance of Adequately Powered Clinical Studies: Response to Khan et al.
Marder SR, Laughren T, Romano SJ. Marder SR, et al. Am J Psychiatry. 2018 Feb 1;175(2):188-189. doi: 10.1176/appi.ajp.2017.17091016r. Am J Psychiatry. 2018. PMID: 29385831 No abstract available.

Why Are Innovative Drugs Failing in Phase III?
Marder SR, Laughren T, Romano SJ. Marder SR, et al. Am J Psychiatry. 2017 Sep 1;174(9):829-831. doi: 10.1176/appi.ajp.2017.17040426. Am J Psychiatry. 2017. PMID: 28859511 No abstract available.