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. 2018 Jan 31;10(1):9.
doi: 10.1186/s13073-018-0518-5.

Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms

Xinyuan Wang  1   2 , Kimberly M Christian  1 , Hongjun Song  1   3   4   5 , Guo-Li Ming  6   7   8   9
Affiliations

Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms

Xinyuan Wang et al. Genome Med. .

Abstract

Breakthroughs on many fronts have provided strong evidence to support synaptic dysfunction as a causal factor for neuropsychiatric diseases. Genetic studies have identified variants implicated in novel biological and synaptic pathways, and animal and patient-derived induced pluripotent stem cell-based models have allowed mechanistic investigations of synaptic dysfunction in pathological processes.

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Conflict of interest statement

Competing interests

The authors declare that they have no competing interests.

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