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. 2018;66(2):178-183.
doi: 10.1248/cpb.c17-00851.

Total Synthesis of Carbazomycins A and B

Siyuan Wu  1 , Shinji Harada  1   2 , Takahiro Morikawa  1 , Atsushi Nishida  1   2
Affiliations
Free article

Total Synthesis of Carbazomycins A and B

Siyuan Wu et al. Chem Pharm Bull (Tokyo). 2018.
Free article

Abstract

Total syntheses of carbazomycins A and B were demonstrated using a ytterbium-catalyzed Diels-Alder reaction with (silyloxyvinyl)indole as a diene. The densely substituted benzene ring of the target compound was successfully constructed by functionalization of a hydrocarbazolone intermediate and subsequent aromatization using N-bromosuccinimide.

Keywords: Diels–Alder reaction; carbazole; carbazomycin; total synthesis; ytterbium.

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