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Case Reports
. 2018 Feb;59(2):152-154.

Malignant rectal melanoma in 2 dogs

Lorelei L Clarke  1 , Daniel R Rissi  1
Affiliations
Case Reports

Malignant rectal melanoma in 2 dogs

Lorelei L Clarke et al. Can Vet J. 2018 Feb.

Abstract
in English, French

Two rare cases of malignant rectal melanoma in dogs are described. Tumors were locally invasive and composed of spindle cells arranged in interweaving bundles, sheets, and nests within preexisting fibrovascular stroma. Mitotic count was high. The diagnosis was achieved based on histopathology and immunohistochemistry for PNL2 and melan-A.

Mélanome rectal malin chez 2 chiens. Deux cas rares de mélanome rectal malin chez les chiens sont décrits. Les tumeurs étaient localement envahissantes et composées de cellules fusiformes disposées en faisceaux entrelacés, de feuilles et de nids dans le stroma fibrovasculaire préexistant. Le compte mitotique était élevé. Le diagnostic a été réalisé sur la base de l’histopathologie et de l’immunohistochimie pour le PNL2 et le melan-A.(Traduit par les auteurs).

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Conflict of interest statement

The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1
Figure 1
Histological appearance of canine malignant anorectal melanoma cells (Case 1). Neoplastic melanocytes arranged in closely apposed bundles and sheets efface the anorectal submucosa. Scattered neoplastic cells with cytoplasmic pigment (upper right and left) are randomly distributed throughout the neoplasm. Hematoxylin and eosin (H&E).
Figure 2
Figure 2
Histological appearance of canine malignant anorectal melanoma cells (Case 2). The neoplasm has many mitoses throughout (arrowheads). H&E.
Figure 3
Figure 3
Immunohistochemical staining of canine malignant anorectal melanoma (Case 2). Neoplastic cells exhibit diffuse PNL2 immunoreactivity.
Figure 4
Figure 4
Immunohistochemical staining of canine malignant anorectal melanoma (Case 1). Neoplastic cells exhibit focal melan-A immunoreactivity. Inset: There is widespread nuclear immunoreactivity for Ki67.
See this image and copyright information in PMC

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