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. 2017 Jul-Dec;8(2):143-148.
doi: 10.4103/0975-5950.221714.

Efficacy of decalcified freeze-dried bone allograft in the regeneration of small osseous defect: A comparative study

Yashmi Jaiswal  1 , Sanjeev Kumar  1 , Vijay Mishra  1 , Puneet Bansal  1 , Kumar Rakshak Anand  1 , Sukumar Singh  1
Affiliations

Efficacy of decalcified freeze-dried bone allograft in the regeneration of small osseous defect: A comparative study

Yashmi Jaiswal et al. Natl J Maxillofac Surg. 2017 Jul-Dec.

Abstract

Aim: To access the efficacy of decalcified freeze-dried bone allograft (DFDBA) in the regeneration of bone following small osseous defect in minor oral surgery.

Objectives: To evaluate the ability of DFDBA to enhance the rate of wound healing and assess radiographic bone density, pain, and infection preoperatively and postoperatively.

Materials and methods: Twenty patients with cysts were assessed. Ten patients were filled with DFDBA (Group 1) and ten without bone graft (Group 2), respectively. Radiographic bone density was assessed on preoperative, intraoperative, and postoperative radiographs on 1st day, 3rd month, and at 6th month using Adobe Photoshop CS6 - Grayscale histogram.

Results: Bone density in Group 1 was found to be significantly higher than in Group 2 on 3rd and 6th month postoperatively with a P = 0.024 and P = 0.016 which was statistically significant. The percentage increase in bone density between both the group was determined and yielded no difference over a period of time, but the difference in percentage increase was markedly higher in Group 1 compared to Group 2 at all the time intervals.

Conclusion: Bone formed as depicted by bone density is significantly higher when DFDBA is used in small bony defects.

Keywords: Allograft; osseous defect; periapical pathology.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Periapical cyst affecting a 19-year-old female, treated by enucleation and bone grafting. (a) Preoperative picture. (b) After flap reflection and curettage of periapical soft tissue lesion. (c) Defect filled using decalcified freeze-dried bone allograft. (d) Sutures given
Figure 2
Figure 2
Periapical cyst affecting a 20-year-old male, treated by enucleation and without bone grafting. (a) Preoperative picture. (b) After flap reflection and curettage of periapical soft tissue lesion. (c) Root-end resection. (d) Sutures given
Figure 3
Figure 3
(a) Intraoperative radiograph (radiovisiography). (b) 3rd month radiograph. (c) 6th month radiograph of a patient treated with decalcified freeze-dried bone allograft
Figure 4
Figure 4
(a) Intraoperative radiograph (radiovisiography). (b) 3rd month radiogragh. (c) 6th month radiograph of a patient treated without bone graft
Figure 5
Figure 5
Adobe Photoshop CS6 software
Graph 1
Graph 1
Intergroup comparison of mean logarithm gray scale histogram values
Graph 2
Graph 2
Percentage increase in the mean gray scale histogram values between both the groups at various time intervals
See this image and copyright information in PMC

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