Animal models of contraception: utility and limitations

doi:10.2147/OAJC.S58754

Review

. 2015 Apr 17:6:27-35.

doi: 10.2147/OAJC.S58754. eCollection 2015.

Animal models of contraception: utility and limitations

Emma R Liechty¹, Ingrid L Bergin¹, Jason D Bell²

Affiliations

¹ Unit for Laboratory Animal Medicine.
² Program on Women's Health Care Effectiveness Research, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.

PMID: 29386922
PMCID: PMC5683139
DOI: 10.2147/OAJC.S58754

Review

Animal models of contraception: utility and limitations

Emma R Liechty et al. Open Access J Contracept. 2015.

. 2015 Apr 17:6:27-35.

doi: 10.2147/OAJC.S58754. eCollection 2015.

Authors

Emma R Liechty¹, Ingrid L Bergin¹, Jason D Bell²

Affiliations

¹ Unit for Laboratory Animal Medicine.
² Program on Women's Health Care Effectiveness Research, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.

PMID: 29386922
PMCID: PMC5683139
DOI: 10.2147/OAJC.S58754

Abstract

Appropriate animal modeling is vital for the successful development of novel contraceptive devices. Advances in reproductive biology have identified novel pathways for contraceptive intervention. Here we review species-specific anatomic and physiologic considerations impacting preclinical contraceptive testing, including efficacy testing, mechanistic studies, device design, and modeling off-target effects. Emphasis is placed on the use of nonhuman primate models in contraceptive device development.

Keywords: contraceptive devices; in vivo; nonhuman primate; preclinical.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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References

1. Alkema L, Kantorova V, Menozzi C, Biddlecom A. National, regional, and global rates and trends in contraceptive prevalence and unmet need for family planning between 1990 and 2015: a systematic and comprehensive analysis. Lancet. 2013;381(9878):1642–1652. - PubMed
1. Brown SS, Eisenberg L, editors. The Best Intentions: Unintended Pregnancy and the Well-Being of Children and Families. Washington, DC, USA: National Academies; 1995. - PubMed
1. Craig AD, Dehlendorf C, Borrero S, Harper CC, Rocca CH. Exploring young adults’ contraceptive knowledge and attitudes: disparities by race/ethnicity and age. Womens Health Issues. 2014;24(3):e281–e289. - PMC - PubMed
1. Bartz D, Shew M, Ofner S, Fortenberry JD. Pregnancy intentions and contraceptive behaviors among adolescent women: a coital event level analysis. J Adolesc Health. 2007;41(3):271–276. - PubMed
1. Bracken J, Graham CA. Young women’s attitudes towards, and experiences of, long-acting reversible contraceptives. Eur J Contracept Reprod Health Care. 2014;19(4):276–284. - PubMed

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[1] Alkema L, Kantorova V, Menozzi C, Biddlecom A. National, regional, and global rates and trends in contraceptive prevalence and unmet need for family planning between 1990 and 2015: a systematic and comprehensive analysis. Lancet. 2013;381(9878):1642–1652. - PubMed

[2] Alkema L, Kantorova V, Menozzi C, Biddlecom A. National, regional, and global rates and trends in contraceptive prevalence and unmet need for family planning between 1990 and 2015: a systematic and comprehensive analysis. Lancet. 2013;381(9878):1642–1652. - PubMed

[3] Brown SS, Eisenberg L, editors. The Best Intentions: Unintended Pregnancy and the Well-Being of Children and Families. Washington, DC, USA: National Academies; 1995. - PubMed

[4] Brown SS, Eisenberg L, editors. The Best Intentions: Unintended Pregnancy and the Well-Being of Children and Families. Washington, DC, USA: National Academies; 1995. - PubMed

[5] Craig AD, Dehlendorf C, Borrero S, Harper CC, Rocca CH. Exploring young adults’ contraceptive knowledge and attitudes: disparities by race/ethnicity and age. Womens Health Issues. 2014;24(3):e281–e289. - PMC - PubMed

[6] Craig AD, Dehlendorf C, Borrero S, Harper CC, Rocca CH. Exploring young adults’ contraceptive knowledge and attitudes: disparities by race/ethnicity and age. Womens Health Issues. 2014;24(3):e281–e289. - PMC - PubMed

[7] Bartz D, Shew M, Ofner S, Fortenberry JD. Pregnancy intentions and contraceptive behaviors among adolescent women: a coital event level analysis. J Adolesc Health. 2007;41(3):271–276. - PubMed

[8] Bartz D, Shew M, Ofner S, Fortenberry JD. Pregnancy intentions and contraceptive behaviors among adolescent women: a coital event level analysis. J Adolesc Health. 2007;41(3):271–276. - PubMed

[9] Bracken J, Graham CA. Young women’s attitudes towards, and experiences of, long-acting reversible contraceptives. Eur J Contracept Reprod Health Care. 2014;19(4):276–284. - PubMed

[10] Bracken J, Graham CA. Young women’s attitudes towards, and experiences of, long-acting reversible contraceptives. Eur J Contracept Reprod Health Care. 2014;19(4):276–284. - PubMed

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Animal models of contraception: utility and limitations

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Animal models of contraception: utility and limitations

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Abstract

Conflict of interest statement

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