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. 2017 Oct;24(5):19-32.
doi: 10.21315/mjms2017.24.5.3. Epub 2017 Oct 26.

Nutritional Compositions and Antiproliferative Activities of Different Solvent Fractions from Ethanol Extract of Cyphomandra betacea (Tamarillo) Fruit

Maisarah Abdul Mutalib  1 , Asmah Rahmat  2 , Faisal Ali  1   3 , Fauziah Othman  4 , Rajesh Ramasamy  5
Affiliations

Nutritional Compositions and Antiproliferative Activities of Different Solvent Fractions from Ethanol Extract of Cyphomandra betacea (Tamarillo) Fruit

Maisarah Abdul Mutalib et al. Malays J Med Sci. 2017 Oct.

Abstract

Background: This study aims to examine various solvent extracts of Cyphomandra betacea (tamarillo) also known as the tree tomato, for their bioactive constituents and antioxidant activity. The study also aims to examine its effect on cancer cell death using two types of cancer cell lines (liver and breast cancer cell).

Methods: The first part of the study evaluates the nutritional composition of tamarillo. Then, phytochemical profiling using GC-MS analysis in ethanolic tamarillo extract was conducted. Different fractions of n-butanol, ethyl acetate and aqueous fractions were obtained from the ethanolic extract of tamarillo. Then, the fractions were subjected to the quantification of total phenol (TPC) and flavonoid contents (TFC), free radical scavenging activity (SA) and also antioxidant activity (AOX) assayed by beta-carotene bleaching (BCB) assay. Finally, the capability of the ethanolic extract of tamarillo and different fractions were evaluated for their anticancer properties.

Results: Findings from this study revealed that the nutritional composition (ash, protein, carbohydrate and total dietary fiber), and mineral levels (calcium, magnesium, potassium and iron) of tamarillo were moderate. The crude ethanol extract of tamarillo contained the highest phenolic and total flavonoid content. FT-IR analysis revealed the presence of alkanes, carboxylic acid, phenol, alkanes, carboxylic acids, aromatics and nitro compounds. Twelve bioactive constituents in tamarillo have been identified through GC-MS analysis. Cytotoxic activity suggests the potential of ethanolic extracts of tamarillo having a chemopreventive effect on breast and liver cancer cells.

Conclusion: This study reveals that tamarillo has substantial antioxidant activity as well as anticancer properties.

Keywords: Cyphomandra betaceae; anticancer activities; antioxidant activity; antiproliferative activities; nutritional composition.

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Figures

Figure 1(a)
Figure 1(a)
Mass spectrum of 2-Methyl[1,3,4]oxadiazole (RT: 8.22)
Figure 1(b)
Figure 1(b)
Mass spectrum of 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl (RT: 31.13)
Figure 1(c)
Figure 1(c)
Mass spectrum of Hexadecanoic acid (Palmitic acid) (RT: 59.17)
Figure 2
Figure 2
(a) Total phenolic content and (b) total flavonoid content of tamarillo different fractions. Data are presented as mean ± standard deviation of triplicate measurements (n = 3)
See this image and copyright information in PMC

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References

    1. Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative stress and antioxidant defense. World Allergy Organ J. 2012;5(1):9–19. https://doi.org/10.1097/WOX.0b013e3182439613. - DOI - PMC - PubMed
    1. Circu ML, Aw TY. Reactive oxygen species, cellular redox systems and apoptosis. Free Radic Biol Med. 2010;48(6):749–762. https://doi.org/10.1016/j.freeradbiomed.2009.12.022. - DOI - PMC - PubMed
    1. Lobo V, Patil A, Phatak AN, Chandra N. Free radicals, antioxidants and functional foods: impact on human health. Pharmacogn Rev. 2010;4(8):118–126. https://doi.org/10.4103/0973-7847.70902. - DOI - PMC - PubMed
    1. Sies H. Oxidative Stress: oxidants and antioxidants. London: Accademic Press; 1991. - PubMed
    1. Ali F, Ranneh Y, Ismail A, Esa NM. Identification of phenolic compounds in polyphenols-rich extract of Malaysian cocoa powder using the HPLC-UV-ESI—MS/MS and probing their antioxidant properties. J Food Sci Technol. 2013;54:2103–2111. https://doi.org/10.1007/s13197-013-1187-4. - DOI - PMC - PubMed