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Review
. 2018 Jan 19:15:1.
doi: 10.1186/s12979-017-0112-5. eCollection 2018.

Ageing: from inflammation to cancer

Giulia C Leonardi #  1 , Giulia Accardi #  2 , Roberto Monastero  3 , Ferdinando Nicoletti  1 , Massimo Libra  1
Affiliations
Review

Ageing: from inflammation to cancer

Giulia C Leonardi et al. Immun Ageing. .

Abstract

Ageing is the major risk factor for cancer development. Hallmark of the ageing process is represented by inflammaging, which is a chronic and systemic low-grade inflammatory process. Inflammation is also a hallmark of cancer and is widely recognized to influence all cancer stages from cell transformation to metastasis. Therefore, inflammaging may represent the biological phenomena able to couple ageing process with cancer development. Here we review the molecular and cellular pathway involved in age-related chronic inflammation along with its potential triggers and their connection with cancer development.

Keywords: Ageing; Cancer; DAMPs; Inflammation; MiRna; Microbiota; Obesity; Senescence.

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Conflict of interest statement

Not applicableNot applicableThe authors declare they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Sources and modulators of inflammaging. Age-related inflammation results from the complex interplay between immunesenscence, cellular senescence, self-debris, obesity, gut microbiota and dietary patterns
See this image and copyright information in PMC

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