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. 2018 Winter;9(1):27-31.
doi: 10.22088/cjim.9.1.27.

Anti-coagulation therapy following coronary endarterectomy in patient with coronary artery bypass graft

Hamdi Reza Vafaey  1 , Mohammad Taghi Salehi Omran  2 , Sadaf Abbaspour  3 , Nadia Banihashem  4 , Ghassem Faghanzadeh Ganji  1
Affiliations

Anti-coagulation therapy following coronary endarterectomy in patient with coronary artery bypass graft

Hamdi Reza Vafaey et al. Caspian J Intern Med. 2018 Winter.

Abstract

Background: Since there is a lack of research on postoperative anticoagulation protocol in patients undergoing coronary artery bypass graft (CABG) / coronary endarterectomy (CE), we recommend a new protocol for anticoagulation in these patients.

Methods: In this double-blind randomized clinical trial study, 52 patients undergoing CABG / CE entered the study and were divided into two groups. In group 1, the patients were given warfarin(international normalized ratio (INR) between 2-3) together with 80 mg aspirin daily for 3 months. In group 2, the patients were given 75 mg plavix daily together with 80 mg aspirin daily for 3 months. We evaluated patients with electrocardiography, echocardiography and checking ceratin phosphokinase MB and troponin I in the several stages. The data were analysed SPSS Version18 software.

Results: There was no significant difference between pre and post-operative Ejection fraction in patients with plavix (P=0.21) and warfarin (P=0.316) regimen. However, wall mrotion score was significantly better in clopidogrel - aspirin patients in late (3 months) post operation (p<0.001).

Conclusions: Since warfarin has serious hemorrhagic complications and requires closed monitoring of serum drug activity by serial INR checking, it is recommended that clopidogrel - aspirin can be the preferred alternative anticoagulation therapy in CABG / CE patients.

Keywords: Clopidogrel; Coronary artery bypass graft; Coronary endarterectomy; Warfarin.

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Conflict of interest statement

The authors declare no conflict of interest with regard to authorship and/or publication of this article.

Figures

Figure1
Figure1
Schematic representation of groups in study
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