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. 2018 Winter;9(1):46-53.
doi: 10.22088/cjim.9.1.46.

The efficacy and safety of two different doses of caffeine in respiratory function of preterm infants

Fatemeh Faramarzi  1 , Mohammadreza Shiran  2 , Mohammadreza Rafati  1 , Roya Farhadi  3 , Ebrahim Salehifar  1 , Maryam Nakhshab  3
Affiliations

The efficacy and safety of two different doses of caffeine in respiratory function of preterm infants

Fatemeh Faramarzi et al. Caspian J Intern Med. 2018 Winter.

Abstract

Background: Caffeine is widely used for prevention of apnea and helps successful extubation from mechanical ventilation. It facilitates the transition from invasive to noninvasive support and reduces duration of continuous positive airway pressure (CPAP) in preterm infants. The optimum caffeine dose in preterm infants has not been well-studied in terms of benefits and risks. We compared efficacy and safety of once versus twice-daily caffeine dose in premature infants.

Methods: This study was a randomized clinical trial conducted in Bu-Ali Sina Teaching Hospital, Sari. Patients with gestational age of <37 weeks were included. Both groups received 20 mg/kg loading dose of caffeine intravenously followed by maintenance dose of 5 mg/kg/day in group 1 or 2.5 mg/kg every 12 hours in group 2. Extubation failure, CPAP failure and possibly adverse reactions were evaluated.

Results: The mean of gestational age and birth weight were 32.27±3.23 (weeks) and 1824.5±702.54 (gr), respectively. The rate of extubation and CPAP failure and length of NICU stay were lower in twice-daily-group with no statistically significant difference. The means of O2 saturations on the first three days of caffeine therapy were higher in twice-daily-group. Caffeine was generally safe and well tolerated.

Conclusions: This study, which assayed short-term effects of caffeine, showed that twice daily caffeine maintenance dose was related to more benefits in facilitating extubation or prevention of CPAP failure in preterm infants. However, there was not statistically significant difference between two groups.

Keywords: CPAP failure; Caffeine; Extubation failure; Preterm infants.

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Conflict of interest statement

There is no conflict of interest.

Figures

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Figure 1
Diagram of the participants
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References

    1. Edwards MO, Kotecha SJ, Kotecha S. Respiratory distress of the term newborn infant. Paediatr Respir Rev. 2013;14:29–37. - PubMed
    1. Subiramanian S, Sweet DG. Management of neonatal respiratory distress syndrome. Paediatr Child Health. 2012;22:518–22.
    1. Sweet DG, Carnielli V, Greisen G, et al. European consensus guidelines on the management of respiratory distress syndrome-2016 update. Neonatology. 2016;111:107–25. - PubMed
    1. Wielenga JM, van den Hoogen A, et al. Protocolized versus non‐protocolized weaning for reducing the duration of invasive mechanical ventilation in newborn infants. Cochrane Database Syst Rev. 2016;3:CD011106. - PMC - PubMed
    1. Steer P, Flenady V, Shearman A, et al. High dose caffeine citrate for extubation of preterm infants: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 2004;89:F499–503. - PMC - PubMed

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