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Case Reports
. 2017 Nov 28;9(11):e1886.
doi: 10.7759/cureus.1886.

Salvage Hypofractionated Radiotherapy in a Progressive Radiation-Induced Angiosarcoma: A Case Report

Elisabetta Bonzano  1 , Marina Guenzi  1 , Renzo Corvò  1
Affiliations
Case Reports

Salvage Hypofractionated Radiotherapy in a Progressive Radiation-Induced Angiosarcoma: A Case Report

Elisabetta Bonzano et al. Cureus. .

Abstract

We report a case of a long-term local control and survival achieved in a patient affected by radiation-induced angiosarcoma (RIA). A 57-year-old woman had a history of breast-conserving surgery and radiation therapy for primary breast cancer. Eight years after the mastectomy, multiple nodal progression was diagnosed as RIA and subsequentially treated by salvage lymph node dissection followed by adjuvant intensified radiotherapy to control the residual disease. Two and a half years later, the patient is alive and cancer-free. This experience shows that radiotherapy may have the potential to be a feasible and effective treatment to control RIA progression, and it may also play a role in the management of RIA as adjuvant.

Keywords: angiosarcoma; breast; case report; nodal progression; radiation-induced; radiotherapy.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. PET/CT scan shows a contralateral recurrence of the angiosarcoma (white arrow)
PET/CT: positron emission tomography/computed tomography
Figure 2
Figure 2. Dose plan
Figure 3
Figure 3. PET/CT negative for nodal disease after multimodality treatment
PET/CT: positron emission tomography/computed tomography
See this image and copyright information in PMC

References

    1. Clinical management of secondary angiosarcoma after breast conservation therapy. Zemanova M, Machalekova K, Sandorova M, et al. http://www.sciencedirect.com/science/article/pii/S1507136713010183. Rep Pract Oncol Radiother. 2014;19:37–46. - PMC - PubMed
    1. Angiosarcoma after breast-conserving therapy. Monroe AT, Feigenberg SJ, Mendenhall NP. Cancer. 2003;97:1832–1840. - PubMed
    1. Sarcoma as a second malignancy after treatment for breast cancer. Yap J, Chuba PJ, Thomas R, et al. Int J Radiat Oncol Biol Phys. 2002;52:1231–1237. - PubMed
    1. Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion. Lucas DR. http://www.archivesofpathology.org/doi/abs/10.1043/1543-2165-133.11.1804.... Arch Pathol Lab Med. 2009;133:1804–1809. - PubMed
    1. Radiation-associated cutaneous atypical vascular lesions and angiosarcoma: clinicopathologic analysis of 42 cases. Brenn T, Fletcher CDM. http://journals.lww.com/ajsp/Abstract/2005/08000/Radiation_Associated_Cu.... Am J Surg Pathol. 2005;29:983–996. - PubMed

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