Reconstruction of mammalian oocytes by germinal vesicle transfer: A systematic review
- PMID: 29387825
- PMCID: PMC5767640
Reconstruction of mammalian oocytes by germinal vesicle transfer: A systematic review
Abstract
Nuclear transfer procedures have been recently applied for clinical and research targets as a novel assisted reproductive technique and were used for increasing the oocyte activity during its growth and maturation. In this review, we summarized the nuclear transfer technique for germinal vesicle stage oocytes to reconstruct the maturation of them. Our study covered publications between 1966 and August 2017. In result utilized germinal vesicle transfer techniques, fusion, and fertilization survival rate on five different mammalian species are discussed, regarding their potential clinical application. It seems that with a study on this method, there is real hope for effective treatments of old oocytes or oocytes containing mitochondrial problems in the near future.
Keywords: Germinal vesicle; Micromanipulation; Nuclear transfer; Oocyte.
Conflict of interest statement
All authors declare no financial or commercial conflict of interest.
Figures
References
-
- Sun QY, Lai L, Bonk A, Prather RS, Schatten H. Cytoplasmic changes in relation to nuclear maturation and early embryo developmental potential of porcine oocytes: effects of gonadotropins, cumulus cells, follicular size, and protein synthesis inhibition. Mol Reprod Dev. 2001;59:192–198. - PubMed
-
- Gao S, Gasparrini B, McGarry M, Ferrier T, Fletcher J, Harkness L, et al. Germinal vesicle material is essential for nucleus remodeling after nuclear transfer. Biol Reprod. 2002;67:928–934. - PubMed
-
- Darbandi S, Darbandi M, Sadeghi MR, Al-Hasani S, Agarwal A, Shirazi A, et al. Experimental strategies towards increasing intracellular mitochondrial activity in oocytes: A systematic review. Mitochondrion. 2016;30:8–17. - PubMed
-
- Neupane J, Vandewoestyne M, Ghimire S, Lu Y, Qian C, Van Coster R, et al. Assessment of nuclear transfer techniques to prevent the transmission of heritable mitochondrial disorders without compromising embryonic development competence in mice. Mitochondrion. 2014;18:27–33. - PubMed
-
- Brown DT, Herbert M, Lamb VK, Chinnery PF, Taylor RW, Lightowlers RN, et al. Transmission of mitochondrial DNA disorders: possibilities for the future. Lancet. 2006;368:87–89. - PubMed
Publication types
LinkOut - more resources
Full Text Sources